Disrupted functional connectivity between the periaqueductal gray and other brain regions in a rat model of recurrent headache.
Disrupted functional connectivity between the periaqueductal gray and other brain regions in a rat model of recurrent headache.
复制标题
复发性头痛大鼠模型中导水管周围灰质和其他大脑区域之间的功能连接中断
DOI：
10.1038/s41598-017-04060-6
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发表时间：
2017-06-21
影响因子：
4.6
通讯作者：
Yu S
中科院分区：
文献类型：
--
作者：
Jia Z;Tang W;Zhao D;Yu S
功能连接（FC）已被用于研究偏头痛的病理生理。我们的目的是在反复脑膜痛觉诱导的大鼠中脑导水管周围灰质（PAG）和其他脑区之间鉴定非典型FC。通过硬膜上置管注入炎症汤（IS）建立清醒大鼠模型。观察静息和面部梳理行为来评估伤害行为。大鼠在注射IS后21 d，在PAG上进行FC分析。注射IS后，大鼠表现出与偏头痛相关的人类行为相关的伤害性行为。PAG显示，模型大鼠前额叶皮层、扣带回和运动皮层的FC增加，基底节区、丘脑背外侧区、内囊区和前边缘皮层的FC减少。大鼠PAG的非典型FC与痛觉、体感加工、情绪加工和疼痛调节的脑区有关，这与偏头痛患者的临床数据一致，表明偏头痛患者静息状态FC的改变可能是头痛发作的结果，并进一步验证了慢性偏头痛大鼠模型。
Functional connectivity (FC) has been used to investigate the pathophysiology of migraine. We aimed to identify atypical FC between the periaqueductal gray (PAG) and other brain areas in rats induced by repeated meningeal nociception. The rat model was established by infusing an inflammatory soup (IS) through supradural catheters in conscious rats. Quiescent and face-grooming behaviors were observed to assess nociceptive behavior. FC analysis seeded on the PAG was performed on rats 21 days after IS infusion. The rats exhibited nociceptive behavior correlates of human behaviors associated with migraine after IS infusion. The PAG showed increased FC with the prefrontal cortex, cingulate gyrus, and motor cortex but decreased FC with the basal ganglia, dorsal lateral thalamus, internal capsule and prelimbic cortex in the rat model. The atypical FC of the PAG with brain regions in the rat model that are involved in nociception, somatosensory processing, emotional processing, and pain modulation are consistent with the clinical data from migraineurs, indicate that resting-state FC changes in migraine patients may be a consequence of headache attacks, and further validate this rat model of chronic migraine.