Expression of cyclooxygenase-2 in advanced stage ovarian serous carcinoma: Correlation with tumor cell proliferation, apoptosis, angiogenesis, and survival
Expression of cyclooxygenase-2 in advanced stage ovarian serous carcinoma: Correlation with tumor cell proliferation, apoptosis, angiogenesis, and survival
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DOI：
10.1016/j.ajog.2004.10.587
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发表时间：
2005-03-01
影响因子：
9.8
通讯作者：
Munkarah, AR
中科院分区：
文献类型：
--
作者：
Ali-Fehmi, R;Morris, RT;Munkarah, AR
目的：环氧化酶-2似乎参与了肿瘤进展过程的多个步骤。本研究旨在探讨环氧化酶-2表达与晚期高级别卵巢癌患者肿瘤增殖、细胞凋亡和血管生成的关系。研究设计：118例高级别和晚期（III， IV）浆液性卵巢癌患者的标本通过免疫组织化学检测环氧化酶-2、Ki-67、血管内皮生长因子和bcl-2的表达。CD34免疫染色检测肿瘤微血管密度。我们研究了环氧化酶-2表达与临床病理特征、肿瘤血管生成（肿瘤微血管密度和血管内皮生长因子表达）、肿瘤增殖和凋亡的关系。观察环氧化酶-2表达对患者生存的影响。结果：环氧化酶-2在肿瘤细胞中的表达与肿瘤增殖和血管生成标志物呈显著正相关。在单因素生存分析中，高环氧化酶-2和高Ki-67表达对患者生存有显著影响(P
Objective: Cyclo-oxygenase-2 seems to be involved at various steps in the processes of tumor progression. The objective of this study was to examine the relationship between cyclo-oxygenase-2 expression and tumor proliferation, apoptosis and angiogenesis in patients with advanced stage high-grade ovarian carcinoma.Study design: Specimens from 118 patients with high-grade and advanced stage (III, IV) serous ovarian carcinoma were evaluated by immunohistochemistry for cyclo-oxygenase-2, Ki-67, vascular endothelial growth factor, and bcl-2 expression. Tumor microvessel density was assessed with CD34 immunostaining. We investigated the relationships between cyclo-oxygenase-2 expression and clinicopathologic characteristics, tumor angiogehesis (tumor microvessel density and vascular endothelial growth factor expression), and tumor proliferation and apoptosis. The effect of cyclooxygenase-2 expression on patient survival was determined.Results: There was a significant positive correlation between cyclo-oxygenase-2 expression in tumor cells and markers of tumor proliferation and angiogenesis. In univariate survival analysis, high cyclo-oxygenase-2 and high Ki-67 expression showed a significant impact of on patient survival (P