Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment.
Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment.
复制标题
靶向癌症干细胞中的信号通路进行癌症治疗
DOI：
10.1155/2017/2925869
复制
发表时间：
2017
影响因子：
4.3
通讯作者：
Hao J
中科院分区：
文献类型：
--
作者：
Koury J;Zhong L;Hao J
Wnt、Hedgehog和Notch途径是正常胚胎发生、发育和止血中的固有信号传导途径。然而，这些途径的功能障碍在多种肿瘤类型和恶性肿瘤中是明显的。具体而言，这些途径的异常激活涉及癌症干细胞（CSC）的调节，癌症干细胞是能够自我更新和分化成异质肿瘤细胞的癌细胞的一小部分。CSC负责肿瘤的起始、生长和复发。在这篇综述中，我们重点关注Wnt，Hedgehog和Notch通路在CSC的干细胞和功能中的作用，并总结了针对这些通路的治疗研究，以消除CSC和改善整体癌症治疗结果。
The Wnt, Hedgehog, and Notch pathways are inherent signaling pathways in normal embryogenesis, development, and hemostasis. However, dysfunctions of these pathways are evident in multiple tumor types and malignancies. Specifically, aberrant activation of these pathways is implicated in modulation of cancer stem cells (CSCs), a small subset of cancer cells capable of self-renewal and differentiation into heterogeneous tumor cells. The CSCs are accountable for tumor initiation, growth, and recurrence. In this review, we focus on roles of Wnt, Hedgehog, and Notch pathways in CSCs' stemness and functions and summarize therapeutic studies targeting these pathways to eliminate CSCs and improve overall cancer treatment outcomes.