SERIAL FIBEROPTIC BRONCHOSCOPIC OBSERVATIONS OF ENDOBRONCHIAL TUBERCULOSIS BEFORE AND EARLY AFTER ANTITUBERCULOSIS CHEMOTHERAPY
SERIAL FIBEROPTIC BRONCHOSCOPIC OBSERVATIONS OF ENDOBRONCHIAL TUBERCULOSIS BEFORE AND EARLY AFTER ANTITUBERCULOSIS CHEMOTHERAPY
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DOI：
10.1378/chest.103.3.673
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发表时间：
1993-03-01
期刊：
影响因子：
9.6
通讯作者：
PARK, CS
中科院分区：
文献类型：
--
作者：
KIM, YH;KIM, HT;PARK, CS
研究目的：为了评估支气管内膜结核的抗结核治疗反应的不同阶段的evolution.Design：一项前瞻性研究之前和之后的试验与9个月的抗结核化疗without steroids.Patients和干预：136支气管内膜病变62例被细分为四种类型，根据最初的纤维支气管镜（FOB）的结果。对29例56个支气管内病变进行随访FOB，观察化疗9个月后3个月内支气管内病变及支气管狭窄的变化。渗出性（59处，43.3%）、溃疡性（13处，9.7%）、瘢痕性（36处，26.5%）和支气管腺性（28处，20.5%）。在56个病灶的重新评估中，所有19个渗出性病灶和所有9个溃疡性病灶均显示完全改善。在瘢痕性病变中，大多数（12个病变中的10个）支气管狭窄无变化，而2个病变显示改善。在支气管腺病变中，18个病变中有6个显示进展性支气管狭窄。总体而言，我们观察到53.6%的反应改善，10.7%的支气管狭窄进展，其余35.7%的反应稳定。进展性病变仅在支气管腺病变中发现。结论：在渗出性、溃疡性和瘢痕性病变中，单独给予抗结核化疗在治疗后早期产生了良好的反应。
Study objective: To evaluate the antituberculous treatment responsiveness of endobronchial tuberculosis in the different stages of evolution.Design: A prospective study before and after trial with 9 months of antituberculosis chemotherapy without steroid.Patients and intervention: One hundred thirty-six endobronchial lesions in 62 patients were subdivided into four types according to initial fiberoptic bronchoscopic (FOB) findings. Follow-up FOB was performed in 29 patients with 56 endobronchial lesions to detect the changes in the initial endobronchial lesion and bronchostenosis within 3 months after completion of 9 months of chemotherapy.Results: The endobronchial lesions could be classified into four types: exudative (59 lesions, 43.3 percent), ulcerative (13 lesions, 9.7 percent), cicatricial (36 lesions, 26.5 percent), and bronchoglandular (28 lesions, 20.5 percent). In the reassessment of 56 lesions, all 19 exudative and all 9 ulcerative lesions showed complete improvement. of the cicatricial lesions, most (10 of 12 lesions) showed no change in bronchostenosis, whereas 2 lesions showed improvement. In the bronchoglandular lesions, 6 of 18 lesions showed progressed bronchostenosis. Overall, we observed improved responses in 53.6 percent, progressed bronchostenosis in 10.7 percent, and stationary responses in the remaining 35.7 percent. The progressed lesions were found only in the bronchoglandular lesions.Conclusion: In the exudative, ulcerative, and cicatricial lesions, the administration of antituberculous chemotherapy alone resulted in favorable responses in the early posttreatment period.