Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity.
Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity.
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超越胆固醇。
DOI：
10.1056/nejm198904063201407
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Witztum,JL
中科院分区：
文献类型：
--
作者：
Steinberg,D;Parthasarathy,S;Carew,TE;Khoo,JC;Witztum,JL
高胆固醇血症是冠心病的重要原因，临床干预研究已经证明了纠正高胆固醇血症的治疗价值。2国家胆固醇教育计划是在这些发现的基础上制定的。3从这个雄心勃勃的计划中，我们可以预见到降低血浆胆固醇水平的方法会越来越好，从而进一步降低冠心病的死亡率。不过，无论我们如何成功行程高胆固醇血症，冠心病也不会消失，因为高胆固醇并非唯一的致病因素。在任何......
IT is now well established that hypercholesterolemia is an important cause of coronary heart disease, and clinical intervention studies have demonstrated the therapeutic value of correcting hypercholesterolemia.1,2The National Cholesterol Education Program has been instituted on the basis of these findings.3From that ambitious program we can anticipate the development of progressively better methods of reducing plasma cholesterol levels and therefore even further decreases in mortality from coronary heart disease. However, no matter how successfully we deal with hypercholesterolemia, coronary heart disease will not disappear, because a high cholesterol level is by no means the only causative factor. At any . . .