Evolution of peripheral lung adenocarcinomas: CT findings correlated with histology and tumor doubling time
Evolution of peripheral lung adenocarcinomas: CT findings correlated with histology and tumor doubling time
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DOI：
10.2214/ajr.174.3.1740763
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发表时间：
2000-03-01
影响因子：
5
通讯作者：
Kido, M
中科院分区：
文献类型：
--
作者：
Aoki, T;Nakata, H;Kido, M
目的，本研究旨在利用CT表现和与肿瘤倍增时间相关的组织学分类来评估周围型肺腺癌的演变。材料和方法。研究对象为34名患者，每名患者的腺癌小于3厘米，所有患者均接受了胸部X线检查，其中10名患者在术前6个月以上接受过CT检查。通过使用 Schwartz 最初描述的方法检查连续 X 线照片来估计肿瘤倍增时间，还通过研究先前接受过 CT 的 10 名患者的 CT 变化来观察肿瘤生长。根据Noguchi等人的标准评估组织学分类（A-F型）。结果。六种 A 型或 B 型腺癌中的 5 种 (83%) 在高分辨率 CT 上显示局部毛玻璃样阴影。所有6个肿瘤的肿瘤倍增时间均超过1年。 21 个 C 型肿瘤中有 15 个 (71%) 在高分辨率 CT 上显示部分磨玻璃样混浊与局部实性衰减。这 21 个 C 型肿瘤中有 10 个（48%）的肿瘤倍增时间超过 1 年。 B型和C型中，术前观察时实性成分或胸膜凹陷和血管汇合的发展增加，D、E和F型的7个肿瘤大多表现为实性衰减，7个肿瘤中有6个（87%）肿瘤倍增时间小于1年。结论。周围型肺腺癌存在两种主要类型。第一种类型在 CT 上表现为局部毛玻璃样混浊，生长缓慢，另一种表现为快速生长的实性衰减。
OBJECTIVE, This study was performed to evaluate the evolution of peripheral lung adenocarcinomas using CT findings and histologic classification related to tumor doubling time.MATERIALS AND METHODS. The subjects were 34 patients, each with an adenocarcinoma smaller than 3 cm, All patients underwent chest radiography and 10 of them had previously undergone CT more than 6 months before surgery. Tumor doubling time was estimated by examining sequential radiographs using the method originally described by Schwartz, Tumor growth was also observed by studying the changes on CT in the 10 patients who had previously undergone CT. The histologic classification (types A-F) was evaluated according to the criteria of Noguchi et al.RESULTS. Five (83%) of the six adenocarcinomas with tumor types A or B showed localized ground-glass opacity on high-resolution CT. All six tumors had a tumor doubling time of more than 1 year. Fifteen (71%) of the 21 tumors with type C showed partial ground-glass opacity mixed with localized solid attenuation on high-resolution CT. Ten (48%) of these 21 type C tumors had a tumor doubling time of more than 1 year. In types B and C, the solid component or the development of pleural indentation and vascular convergence increased during observation before surgery, All seven tumors with types D, E, and F showed mostly solid attenuation, and the tumor doubling time was less than 1 year in six (87%) of the seven tumors.CONCLUSION. Two main types of peripheral lung adenocarcinoma exist. The first type appears on CT as a localized ground-glass opacity with slow growth, and the other appears as a solid attenuation with rapid growth.