Selective N-alkylation of indoles with primary alcohols using a Pt/HBEA catalyst
Selective N-alkylation of indoles with primary alcohols using a Pt/HBEA catalyst
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DOI：
10.1039/c4gc01419g
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发表时间：
2015
期刊：
影响因子：
9.8
通讯作者：
S. H. Siddiki;K. Kon;K. Shimizu
中科院分区：
文献类型：
--
作者：
S. H. Siddiki;K. Kon;K. Shimizu
负载pt的HBEA （H+交换BEA沸石）是一种有效的、可重复使用的多相催化剂，用于在无添加剂的条件下与伯脂肪醇和苯基醇进行区域选择性n烷基化反应。结构和机理研究表明，Pt金属簇上的Pt0位点与沸石上的Bronsted酸位点存在协同机制，其中Pt0位点负责脱氢/加氢步骤，Bronsted酸位点负责吲哚与醛的区域选择性缩合成烯胺中间体。
Pt-loaded HBEA (H+-exchanged BEA zeolite) is found to be an effective and reusable heterogeneous catalyst for regioselective N-alkylation of indoles with primary aliphatic and benzylic alcohols under additive-free conditions driven by the borrowing-hydrogen methodology. Structural and mechanistic studies suggest a cooperative mechanism of the Pt0 site on Pt metal clusters and the Bronsted acid site of the zeolite, in which the Pt0 site is responsible for dehydrogenation/hydrogenation steps and the Bronsted acid site is responsible for the regioselective condensation of indoles with aldehydes to the enamine intermediate.