New phthalideisoquinoline hemiacetal alkaloid derivatives from Corydalis decumbens
New phthalideisoquinoline hemiacetal alkaloid derivatives from Corydalis decumbens
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延胡索中新型苯酞异喹啉半缩醛生物碱衍生物
DOI：
10.1016/j.fitote.2020.104494
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发表时间：
2020
期刊：
影响因子：
3.4
通讯作者：
Zhengyu Cao
中科院分区：
文献类型：
--
作者：
Chun-Lei Zhang;Qi-Long Huang;Qian Zhu;Juan Chen;Fan Zhang;Zhengyu Cao
从延胡索的鳞茎中分离得到两个新的邻苯二甲基异喹啉半缩醛生物碱衍生物，命名为新的邻苯二甲酸异喹啉半缩醛生物碱A和B(1和2)，以及4个已知生物碱(3-6)。通过1D/2D核磁共振和电子捕获数据分析、量子化学电子捕获计算和X-射线衍射分析对其结构进行了表征。其中，化合物2是第一个天然存在的含2-吡咯烷酮的邻苯二甲酸异喹啉半缩醛生物碱衍生物。对分离得到的化合物进行了神经元兴奋性活性检测。
Two new phthalideisoquinoline hemiacetal alkaloid derivatives, named corybensines A and B (1 and 2), and four known alkaloids (3-6) were isolated from the bulbs of Corydalis decumbens. Their structures were characterized by analysis of 1D/2D NMR and ECD data, quantum chemical ECD calculations, and X-ray diffraction analysis. Among them, compound 2 represents the first naturally occurring phthalideisoquinoline hemiacetal alkaloid derivative with a 2-pyrrolidinone moiety. The activity of the isolated compounds towards neuronal excitability was examined.