CIGARETTE SMOKERS SELF-ADMINISTER INTRAVENOUS NICOTINE
CIGARETTE SMOKERS SELF-ADMINISTER INTRAVENOUS NICOTINE
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DOI：
10.1016/0091-3057(83)90099-0
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发表时间：
1983-01-01
影响因子：
3.6
通讯作者：
JASINSKI, DR
中科院分区：
文献类型：
--
作者：
HENNINGFIELD, JE;MIYASATO, K;JASINSKI, DR
吸烟的人类志愿者有机会按下一个杠杆，结果静脉注射生理盐水或尼古丁。尼古丁注射的模式与单位剂量有关，而生理盐水注射的模式变化很大。志愿者报告说，尼古丁产生的主观影响与服用吗啡或可卡因等滥用药物产生的影响相似。
Human volunteers who smoked cigarettes were given the opportunity to press a lever that resulted in i.v. injections of saline or nicotine. Nicotine injections were taken in orderly patterns that were related to unit dose, while patterns of saline injections varied widely. Volunteers reported that nicotine produced subjective effects similar to those produced by administration of abused drugs such as morphine or cocaine.