Effects of vildagliptin, a DPP-4 inhibitor, in elderly diabetic patients with mild cognitive impairment
Effects of vildagliptin, a DPP-4 inhibitor, in elderly diabetic patients with mild cognitive impairment
复制标题
DOI：
10.1016/j.archger.2019.06.001
复制
发表时间：
2019-09-01
影响因子：
4
通讯作者：
Vacante, Marco
中科院分区：
文献类型：
--
作者：
Borzi, Antonio Maria;Condorelli, Giovanni;Vacante, Marco
前言：在老年人中，2型糖尿病与轻度认知损害之间的关系尚不清楚。与年轻人相比，这两种疾病在老年人中更常见。一些抗糖尿病药物似乎对轻度认知障碍的演变有积极影响。为探讨二肽基多肽酶-4(DPP-4)酶抑制剂维格列汀对经简易智力状态检查(MMSE)证实的老年糖尿病轻度认知损害(MCI)患者认知功能的影响，将60例老年糖尿病患者随机分为2组：A组30例，糖化血红蛋白(HbA)7.5%，应用二甲双胍联合维格列汀治疗。结果：两组患者治疗前空腹血糖(FPG)、糖化血红蛋白(HbA(1)c)、空腹血糖(Fbg)、糖化血红蛋白(HbA(1)c)差异有统计学意义(P<0.001)。组内比较，A组MMSE评分下降显著(P<0.05)，B组HbA1c下降(P=0.01)。结论：维达格列汀与二甲双胍联用可维持MMSE评分，对认知功能具有保护作用。
Introduction: There is an unclear association between type 2 diabetes and mild cognitive impairment in the elderly. Both diseases are more prevalent in the older adults compared to the younger counterpart. Some antidiabetic drugs seem to influence positively the evolution of mild cognitive impairment. This retrospective study investigated the effect of vildagliptin, an inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4), on the cognitive functioning of elderly diabetic patients with mild cognitive impairment (MCI) documented at mini mental state examination (MMSE).Methods: We included 60 diabetic elderly people which were divided in 2 groups: Group A, 30 patients with HbA(1)c (glycated hemoglobin) 7.5%, and treated with metformin plus vildagliptin. We collected data on MMSE, fasting plasma glucose (FPG) and HbA(1)c at baseline and after 180 +/- 10 days from the beginning of treatment.Results: The two groups exhibited significantly different values in FPG (P < 0.05) and HbA(1)c (P < 0.01) at baseline, and in MMSE score (P < 0.001) after treatment. The intragroup comparison showed a significant (P < 0.05) reduction in MMSE score in group A, and in HbA1c (P = 0.01) in group B.Conclusion: Vildagliptin in addition to metformin resulted in the maintenance of MMSE score, showing a protecting role on cognitive functioning compared to the metformin only group.