Boronic acid-modified alginate enables direct formation of injectable, self-healing and multistimuli-responsive hydrogels
Boronic acid-modified alginate enables direct formation of injectable, self-healing and multistimuli-responsive hydrogels
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DOI：
10.1039/c7cc00765e
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发表时间：
2017-03-21
影响因子：
4.9
通讯作者：
Diaz Diaz, David
中科院分区：
文献类型：
--
作者：
Pettignano, Asja;Grijalvo, Santiago;Diaz Diaz, David
海藻酸盐与硼酸基团的一步功能化允许在基本条件下自发形成生物相容水凝胶，而不需要额外的补充分子或交联剂。与海藻酸吡喃糖环上的邻位二醇形成的硼酸酯键的动态性质为材料提供了显著的自愈、注射和多刺激响应性能。
One-step functionalization of alginate with boronic acid groups allowed spontaneous formation of biocompatible hydrogels under basic conditions without additional complementary molecules or crosslinking agents. The dynamic nature of boronate ester bonds formed with vicinal diols present on alginate pyranose rings provided remarkable self-healing, injectable and multi-stimuli responsive properties to the material.