Evidence for a dynamic host-para-site relationship in e-negative hepatitis B carriers
Evidence for a dynamic host-para-site relationship in e-negative hepatitis B carriers
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DOI：
10.1002/jmv.10241
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发表时间：
2002-12-01
影响因子：
12.7
通讯作者：
Boxall, EH
中科院分区：
文献类型：
--
作者：
Tedder, RS;Ijaz, S;Boxall, EH
抗乙型肝炎病毒（HBe）携带者被认为具有低传染性，B肝炎病毒（HBV）DNA水平远低于HBeAg携带者。然而，HBV DNA在抗HBe携带者中的时间稳定性仍然很差。英国卫生部指南使用HBV DNA水平来确定HBV感染的医护人员是否可以执行易感染程序。从147名携带者中分离了1-23年的两份样本，分析了前C变异和HBV DNA水平。15例HBeAg携带者HBV DNA维持在较高水平。在随访评估期间，11名出现抗HBe的个体的DNA减少了5 log（10）倍。抗-HBe携带者HBV DNA水平的比例变化与HBeAg携带者相似，尽管抗-HBe携带者随访较长时间后病毒DNA的变化有更明显的趋势。在20个抗-HBe携带者中的更近距离采样表明，DNA水平在短时间内波动很大。一开始血清转氨酶和前C区突变状态不能预测HBV DNA水平波动的患者。HBV DNA低于检测阈值（
Anti-hepatitis Be (HBe) carriers are perceived as having low infectivity, with hepatitis B virus (HBV) DNA levels far below those seen in the HBeAg carrier. However, the temporal stability of HBV DNA in anti-HBe carriers remains poorly characterised. UK Department of Health guidelines use HBV DNA levels to define whether HBV-infected health care workers may perform exposure-prone procedures. Two samples separated by 1-23 years available from 147 carriers were analysed for precore variants and HBV DNA levels. Among 15 HBeAg carriers, HBV DNA was maintained at high levels. There was a 5 log(10) fold reduction in DNA in 11 individuals who developed anti-HBe during follow-up evaluation. Proportional changes in HBV DNA levels in anti-HBe carriers were similar to those in HBeAg carriers, although there was a trend for changes in viral DNA to be more marked in anti-HBe carriers followed up for longer periods. Closer sampling in 20 anti-HBe carriers demonstrated large fluctuations of DNA levels over short periods. Serum transaminases and precore mutant status at the outset failed to predict those in whom HBV DNA levels fluctuated. HBV DNA was below the detection threshold (