Metabolic Changes of Brain Developmental Venous Anomalies on 18F-FDG-PET
Metabolic Changes of Brain Developmental Venous Anomalies on 18F-FDG-PET
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DOI：
10.1016/j.acra.2018.05.021
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发表时间：
2019-04-01
影响因子：
4.8
通讯作者：
Nabavizadeh, S. Ali
中科院分区：
文献类型：
--
作者：
Lazor, Jillian W.;Schmitt, J. Eric;Nabavizadeh, S. Ali
目的：探讨发育性静脉畸形(DVA)对代谢的影响及其与常规磁共振成像(MRI)的关系。材料和方法：对DVA患者的MRI和脑18F-FDG-PET检查进行回顾性分析。常规MRI用于确定DVA的数目、位置、大小和相关的实质表现，如萎缩、出血、海绵状细胞瘤、毛细血管扩张、皮质发育不良/多小脑回和白质信号异常。用F-18-FDG-PET对DVA引流区域的相对代谢进行定性和定量测量。结果：54例受试者57个DVA进入分析。38%的患者与F-18-FDG-PET定性和定量代谢异常有关，除一例外，所有DVA周围实质中的代谢降低。引流灰质的DVA比仅引流白质的DVA更容易发生代谢低下，提示DVA对(18)F-FDG-PET的代谢作用可能被低估。结论：相当一部分DVA的引流区域存在代谢异常，提示这些异常是具有异常生理特征的血管病变。
Rationale and Objectives: To determine the metabolic effects of developmental venous anomalies (DVAs) and to correlate those effects with conventional magnetic resonance imaging (MRI) findings.Materials and Methods: We conducted a retrospective review of MRI and brain 18F-fluorodeoxyglucose positron emission tomography (F-18-FDG-PET) examinations in subjects with DVAs. Conventional MRI was used to determine DVA number, location, size, and associated parenchymal findings such as atrophy, hemorrhage, cavernoma, capillary telangiectasia, cortical dysplasia/polymicrogyria, and white matter signal abnormality. Qualitative and quantitative measures of relative metabolism in the drainage territory of the DVA were measured on F-18-FDG-PET.Results: Fifty-four subjects with 57 DVAs were included in the analysis. 38% were associated with qualitative and quantitative metabolic abnormalities on F-18-FDG-PET, with decreased metabolism in the parenchyma surrounding all but one of these DVAs. DVAs draining gray matter were significantly more likely to be hypometabolic than those draining only white matter, suggesting that the metabolic effects of DVAs may be underestimated on( 18)F-FDG-PET.Conclusion: Altered metabolism is seen in the drainage territory of a significant proportion of DVAs, suggesting that these anomalies are vascular lesions with abnormal physiologic features.