Remodelling of spared proprioceptive circuit involving a small number of neurons supports functional recovery.
Remodelling of spared proprioceptive circuit involving a small number of neurons supports functional recovery.
复制标题
涉及少数神经元的较低的本体感受电路的重塑支持功能恢复。
DOI：
10.1038/ncomms7079
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发表时间：
2015-01-19
影响因子：
16.6
通讯作者：
Zou Y
中科院分区：
文献类型：
--
作者：
Hollis ER 2nd;Ishiko N;Pessian M;Tolentino K;Lee-Kubli CA;Calcutt NA;Zou Y
研究表明，通过中枢神经系统部分损伤中剩余回路的可塑性和适应性，可以实现有限的功能恢复，尽管在这些情况下出现的新回路尚未被明确识别或表征。我们在这里表明，从背根神经节到少量背柱神经元（股薄核的尾部延伸）的突触接触随着时间的推移经历了重塑，其与丘脑的连接在精确的颈椎1级病变中幸存。这些连接支持调节损伤范例中的本体感觉功能恢复，因为沉默或消除重塑的电路完全废除了后肢恢复的本体感觉功能。此外，我们发现阻断排斥性 Wnt 信号传导会增加轴突可塑性和突触连接，从而促进更大的功能恢复。
Studies show that limited functional recovery can be achieved by plasticity and adaptation of the remaining circuitry in partial injuries in the central nervous system, although the new circuits that arise in these contexts have not been clearly identified or characterized. We show here that synaptic contacts from dorsal root ganglions to a small number of dorsal column neurons, a caudal extension of nucleus gracilis, whose connections to the thalamus are spared in a precise cervical level 1 lesion, underwent remodeling over time. These connections support proprioceptive functional recovery in a conditioning lesion paradigm, as silencing or eliminating the remodelled circuit completely abolishes the recovered proprioceptive function of the hindlimb. Furthermore, we show that blocking repulsive Wnt signalling increases axon plasticity and synaptic connections that drive greater functional recovery.