Mechanical properties of a reversible, DNA-crosslinked polyacrylamide hydrogel
Mechanical properties of a reversible, DNA-crosslinked polyacrylamide hydrogel
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DOI：
10.1115/1.1645529
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发表时间：
2004-02-01
影响因子：
1.7
通讯作者：
Langrana, NA
中科院分区：
文献类型：
--
作者：
Lin, DC;Yurke, B;Langrana, NA
介绍了一种具有可逆DNA交联的聚丙烯酰胺凝胶的力学性能。在这个系统中，三条DNA链取代了传统的化学交联剂。与热固性化学交联聚丙烯酰胺不同，这种新型水凝胶是热可逆的；通过引入特定的脱氧核糖核酸链，不需要增加热量就可以进行交联解离。这种水凝胶的特征是发生凝胶的临界交联度。在临界点以下，存在一个特征温度，在该温度观察到粘度发生转变。材料的温度相关粘度和弹性模量都是交联度的函数。
Mechanical properties of a polyacrylamide gel with reversible DNA crosslinks are presented. In this system, three DNA strands replace traditional chemical crosslinkers. In contrast to thermoset chemically crosslinked polyacrylamide, the new hydrogel is thermoreversible; crosslink dissociation without the addition of heat is also feasible by introducing a specific removal DNA strand. This hydrogel is characterized by a critical crosslink concentration at which gelation occurs. Below the critical point, a characteristic temperature exists at which a transition in viscosity is observed. Both temperature-dependent viscosity and elastic modulus of the material are functions of crosslink density.