Electrophysiological responses of rat olfactory tubercle neurons to biologically relevant odours
Electrophysiological responses of rat olfactory tubercle neurons to biologically relevant odours
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DOI：
10.1111/j.1460-9568.2011.07940.x
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发表时间：
2012-01
影响因子：
3.4
通讯作者：
O. Rampin;Camille Bellier;Y. Maurin
中科院分区：
文献类型：
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作者：
O. Rampin;Camille Bellier;Y. Maurin
生物相关的气味被用来刺激麻醉雄性大鼠的嗅结节神经元。在记录的120个神经元中，有118个显示自发活动（平均放电频率，15.0 ± 1.4峰/秒）。将98个神经元暴露于以下四种气味来源中的至少一种：空小瓶，或含有食物颗粒的小瓶（熟悉的气味），发情期大鼠粪便样本（同种性气味）或雄性狐狸粪便样本（捕食者气味）。神经元对活性变化的反应比例与施加的气味显着相关。重复相同气味的刺激引起相同的活动变化。50%至70%的神经元活动变化不伴随呼吸变化。56个神经元连续暴露于所有四种气味，其中38个神经元对至少一种气味表现出活性变化。神经元对一种气味的反应不受它对前一种气味的反应的影响，没有神经元对所有气味的反应都是一样的。相反，没有气味引起这群神经元的独特反应。然而，兴奋，抑制和不敏感的神经元的比例显着依赖于所施加的气味，这表明嗅结节神经元的招聘是直接依赖于气味的生物学意义。
Biologically relevant odours were used to stimulate olfactory tubercle neurons in anaesthetized male rats. Among 120 recorded neurons, 118 showed spontaneous activity (mean firing rate, 15.0 ± 1.4 spikes/s). Ninety‐eight neurons were exposed to at least one of the four following odour sources: an empty vial, or a vial containing food pellets (familiar odour), a sample of oestrous rat faeces (conspecific sexual odour), or a sample of male fox faeces (predator odour). The proportion of neurons responding with a change in activity was significantly linked to the odour applied. Repetition of the stimulation with the same odour elicited the same activity change. Between 50 and 70% of neuronal activity changes were not accompanied by respiration changes. Fifty‐six neurons were exposed successively to all four odours, and 38 of them showed an activity change in response to at least one. The response of a neuron to an odour was not affected by its response to the previous one, and no neuron responded in the same manner to all odours. Conversely, no odour elicited a unique response in this population of neurons. However, the proportions of excited, inhibited and insensitive neurons depended significantly on the odour applied, suggesting that the recruitment of olfactory tubercle neurons is directly dependent on the biological significance of the odour.