TRPM7 kinase mediates hypomagnesemia-induced seizure-related death.
TRPM7 kinase mediates hypomagnesemia-induced seizure-related death.
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DOI：
10.1038/s41598-023-34789-2
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发表时间：
2023-05-15
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
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作者：
Hypomagnesemia (HypoMg) can cause seizures and death, but the mechanism is unknown. Transient receptor potential cation channel subfamily M 7 (TRPM7) is a Mg transporter with both channel and kinase function. In this study, we focused on the kinase role of TRPM7 in HypoMg-induced seizures and death. Wild type C57BL/6J mice and transgenic mice with a global homozygous mutation in the TRPM7 kinase domain (TRPM7K1646R, with no kinase function) were fed with control diet or a HypoMg diet. After 6 weeks of HypoMg diet, mice had significantly decreased serum Mg, elevated brain TRPM7, and a significant rate of death, with females being most susceptible. Deaths were immediately preceded by seizure events. TRPM7K1646R mice showed resistance to seizure-induced death. HypoMg-induced brain inflammation and oxidative stress were suppressed by TRPM7K1646R. Compared to their male counterparts, HypoMg female mice had higher levels of inflammation and oxidative stress in the hippocampus. We concluded that TRPM7 kinase function contributes seizure-induced deaths in HypoMg mice and that inhibiting the kinase reduced inflammation and oxidative stress.
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影响因子：
6.6
作者：
O-Uchi, Jin;Jhun, Bong Sook;Sheu, Shey-Shing
通讯作者：
Sheu, Shey-Shing
影响因子：
5.4
作者：
Liu M;Liu H;Feng F;Xie A;Kang GJ;Zhao Y;Hou CR;Zhou X;Dudley SC Jr
通讯作者：
Dudley SC Jr
影响因子：
5.5
作者：
通讯作者：
--
影响因子：
6.1
作者：
Fulton RE;Pearson-Smith JN;Huynh CQ;Fabisiak T;Liang LP;Aivazidis S;High BA;Buscaglia G;Corrigan T;Valdez R;Shimizu T;Patel MN
通讯作者：
Patel MN
影响因子：
4.5
作者：
Arjona FJ;de Baaij JH;Schlingmann KP;Lameris AL;van Wijk E;Flik G;Regele S;Korenke GC;Neophytou B;Rust S;Reintjes N;Konrad M;Bindels RJ;Hoenderop JG
通讯作者：
Hoenderop JG