Molecular biology of Fusarium mycotoxins
Molecular biology of Fusarium mycotoxins
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DOI：
10.1016/j.ijfoodmicro.2007.07.024
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发表时间：
2007-10-20
影响因子：
5.4
通讯作者：
Proctor, R. H.
中科院分区：
文献类型：
--
作者：
Desjardins, A. E.;Proctor, R. H.
20 世纪末，镰刀菌真菌毒理学进入了基因组学时代。凭借现有的禾谷镰刀菌和轮枝镰孢菌的完整基因组以及多个镰刀菌基因表达序列数据库，世界各地的研究人员正在快速鉴定霉菌毒素生物合成和调控基因。迄今为止，已在镰刀菌中鉴定出七类霉菌毒素生物合成基因或基因簇；四个是木贼素、伏马菌素、镰孢菌素和玉米赤霉烯酮的聚酮合酶基因簇。其他镰刀菌毒素生物合成基因包括单端孢霉烯族萜烯环化酶基因簇、恩尼亚汀类环肽合成酶和丁烯酸内酯细胞色素 P450。从美国农业部的角度来看，镰刀菌分子生物学研究的最终目标是减少谷物中的霉菌毒素。考虑到这一目标，工作重点是确定可用于霉菌毒素控制的霉菌毒素生物合成和调节的各个方面。关于真菌和植物基因组和基因表达的新信息将继续提供对真菌-植物相互作用重要的基因信息，并促进开发针对镰刀菌感染和霉菌毒素污染的作物育种和工程改造的有针对性的方法。由 Elsevier B.V. 出版
As the 20th century ended, Fusarium mycotoxicology entered the age of genomics. With complete genomes of Fusarium graminearum and F verticillioides and several Fusarium gene expression sequence databases on hand, researchers worldwide are working at a rapid pace to identify mycotoxin biosynthetic and regulatory genes. Seven classes of mycotoxin biosynthetic genes or gene clusters have been identified in Fusarium to date; four are polyketide synthase gene clusters for equisetin, fumonisins, fusarins, and zearalenones. Other Fusarium mycotoxin biosynthetic genes include a terpene cyclase gene cluster for trichothecenes, a cyclic peptide synthetase for enniatins, and a cytochrome P450 for butenolide. From the perspective of the United States Department of Agriculture, the ultimate goal of research on Fusarium molecular biology is to reduce mycotoxins in cereal grains. With this goal in mind, efforts have focused on identifying aspects of mycotoxin biosynthesis and regulation that can be exploited for mycotoxin control. New information on fungal and plant genomes and gene expression will continue to provide information on genes important for fungal-plant interactions and to facilitate the development of targeted approaches for breeding and engineering crops for resistance to Fusarium infection and mycotoxin contamination. Published by Elsevier B.V.