Recruitment of population-based controls for ALS cases from the National ALS Registry.
Recruitment of population-based controls for ALS cases from the National ALS Registry.
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DOI：
10.1080/21678421.2021.1887262
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发表时间：
2021-08
影响因子：
2.8
通讯作者：
Talbott, Evelyn O.
中科院分区：
文献类型：
--
作者：
Bear, Todd M.;Malek, Angela M.;Foulds, Abigail;Rager, Judith;Deperrior, Sarah E.;Vena, John E.;Larson, Theodore C.;Mehta, Paul;Horton, D. Kevin;Talbott, Evelyn O.
2010年，美国有毒物质和疾病登记署（ATSDR）创建了国家ALS登记处（登记处），以检查ALS的流行病学和潜在的危险因素。目前，我们正在招募基于人群的控制流行病学病例对照研究，以检查ALS的环境危险因素，使用本注册表。到目前为止，我们已经招募了181名非疾病的、基于人群的对照组，用于与登记病例（n = 280）进行比较。在这里，我们报告我们的招聘方法的控制和相关的响应率和成本。符合条件的ALS病例具有完整的危险因素调查数据，DNA分析和持久性有机污染物（POP）的血液浓度。年龄，性别和县匹配的控制，确定了商业/消费者数据库使用有针对性的固定电话样本。合格的控制同意，调查，并邮寄持久性有机污染物的血液分析同意书。同意后，安排静脉切开术。我们在2018年9月至2020年3月期间为42个州的181个潜在病例发送了3760封招募信。在进行电话联系并确定合格性后，146名对照同意参与（应答率= 11.4%，合作率= 22.8%）。到目前为止，127名对照完成了调查和血液检查。虽然对照组与病例在年龄、性别和县等方面相匹配，但不匹配的特征（如吸烟）在统计学上没有差异。面试和奖励费用估计为每次完整参与211.85美元。招募匹配的基于人群的对照组与登记研究中的病例进行比较，以进行一项涉及完成详细调查和提供血液标本的研究，这是相对可行且具有成本效益的。这种招募方法可用于其他罕见疾病的病例对照研究。
In 2010, the United States Agency for Toxic Substances and Disease Registry (ATSDR) created the National ALS Registry (Registry) to examine the epidemiology of ALS and potential risk factors. We are currently recruiting population-based controls for an epidemiologic case-control study to examine ALS environmental risk factors using this Registry. To date, we have recruited 181 non-diseased, population-based controls for comparison to Registry cases (n = 280). Here we report our recruitment methods for controls and the associated response rates and costs. Eligible ALS cases had complete risk factor survey data, DNA analysis, and blood concentrations of persistent organic pollutants (POPs). Age, sex, and county-matched controls were identified from commercial/consumer databases using a targeted landline phone sample. Eligible controls were consented, surveyed, and mailed the POPs’ blood analysis consent form. Once consented, phlebotomy was scheduled. We mailed 3760 recruitment letters for 181 potential case-matches across 42 states between 9/2018 and 3/2020. After making phone contact and determining eligibility, 146 controls agreed to participate (response rate = 11.4%, cooperation rate = 22.8%). To date, 127 controls completed the survey and bloodwork. Though controls were matched to cases on age, sex, and county, unmatched characteristics (e.g. smoking) did not differ statistically. Interviewing and incentive costs are estimated at $211.85 per complete participation. Recruiting matched population-based controls for comparison to cases from the Registry for a study involving completion of a detailed survey and blood specimen provision is relatively feasible and cost effective. This recruitment method could be useful for case-control studies of other rare disorders.
DOI：
10.1080/21678421.2019.1612435
发表时间：
2019-07-03
影响因子：
2.8
作者：
Raymond, Jaime;Oskarsson, Bjorn;Horton, Kevin
通讯作者：
Horton, Kevin
影响因子：
33.9
作者：
Mehta, Paul;Horton, D. Kevin;Iskander, John
通讯作者：
Iskander, John
影响因子：
3.7
作者：
Bryan L;Kaye W;Antao V;Mehta P;Muravov O;Horton DK
通讯作者：
Horton DK