Expression of USP22 and the chromosomal passenger complex is an indicator of malignant progression in oral squamous cell carcinoma
Expression of USP22 and the chromosomal passenger complex is an indicator of malignant progression in oral squamous cell carcinoma
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DOI：
10.3892/ol.2018.9837
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发表时间：
2019-02-01
期刊：
影响因子：
2.9
通讯作者：
Qi, Guangying
中科院分区：
文献类型：
--
作者：
Liu, Tian;Liu, Jing;Qi, Guangying
口腔癌是一种常见的头颈部癌症。口腔鳞状细胞癌（OSCC）占头颈部癌总病例的近90%。泛素特异性蛋白酶22（USP 22）是一种去泛素化水解酶，并且它在各种类型的癌症中高度表达，这些癌症通常也具有不良预后。Aurora-B和Survivin属于染色体乘客复合体，也在许多类型的癌症中高度表达。本研究旨在探讨USP 22在口腔鳞癌中的表达及其与Aurora-B、Survivin的相关性，以及USP 22在口腔鳞癌中的临床病理特征。USP 22在口腔鳞状细胞癌中高表达。USP 22过表达与淋巴结转移和组织学分级有关（P
Oral cancer is a common cancer of the head and neck. Oral squamous cell carcinoma (OSCC) represents almost 90% of the total cases of head and neck cancer. Ubiquitin-specific protease 22 (USP22) is a deubiquitinating hydrolase, and it is highly expressed in various types of cancer, which also typically have a poor prognosis. Aurora-B and Survivin, which belong to the chromosomal passenger complex, are also highly expressed in a number of types of cancer. In the present study, USP22 expression and its associations with Aurora-B and Survivin, and the clinicopathological features in OSCC were explored. USP22 is highly expressed in OSCC. Overexpression of USP22 is associated with lymph node metastasis and histological grade (P