THE NATURAL-HISTORY OF HUNTINGTON DISEASE - POSSIBLE ROLE OF AGING GENES
THE NATURAL-HISTORY OF HUNTINGTON DISEASE - POSSIBLE ROLE OF AGING GENES
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DOI：
10.1002/ajmg.1320180115
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发表时间：
1984-01-01
期刊：
影响因子：
--
通讯作者：
YU, P
中科院分区：
文献类型：
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作者：
FARRER, LA;CONNEALLY, PM;YU, P
考虑一个模型，其中控制衰老的遗传因素也改变了亨廷顿病（HD）基因的表达。发病年龄（AO）和死亡年龄（AD）之间的受影响的父母和他们的受影响的后代显着相关系数。与该假设更相关的是，正常同胞的平均AD与患病父母的AD（r = 0.57）和其患病同胞的平均AD（r = 0.54）之间的相关性也是显著的。当发病而不是死亡的影响个人的系数分别为0.46和0.52。正常父母的AD与其患病（r = 0.39）和正常（r = 0.36）后代的AD显著相关。目前遗传理论的老化和相关的趋势，在HD进行了讨论。来自老年学研究的结果和证据支持这样的假设，即具有上级衰老基因的HD基因携带者在生命后期表现出症状，并且比具有低级衰老基因的人寿命更长。
A model is considered in which genetic factors that control aging also modify expression of the Huntington disease (HD) gene. Significant correlation coefficients were obtained for age-at-onset (AO) and age-at-death (AD) between affected parents and their affected offspring. More relevant to the hypothesis, the correlations between mean AD in normal sibs and AD in the affected parent (r = 0.57) and mean AD in their affected sibs (r = 0.54) are also significant. When onset is used instead of death for affected individuals the coefficients are 0.46 and 0.52, respectively. AD in the normal parent is significantly correlated with AD in his affected (r = 0.39) and normal (r = 0.36) offspring. Current genetic theories on aging and related trends in HD are discussed. The results and evidence from gerontological studies support the hypothesis that HD gene carriers with superior aging genes manifest symptoms later in life and have increased longevity over those with inferior aging genes.