The beta gamma subunits of GTP-binding proteins activate the muscarinic K+ channel in heart.
The beta gamma subunits of GTP-binding proteins activate the muscarinic K+ channel in heart.
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发表时间：
1987
期刊：
影响因子：
64.8
通讯作者：
D. Logothetis;Y. Kurachi;J. Galper;E. Neer;D. Clapham
中科院分区：
文献类型：
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作者：
D. Logothetis;Y. Kurachi;J. Galper;E. Neer;D. Clapham
从牛大脑皮层纯化的鸟嘌呤核苷酸调节蛋白亚基被用来灌注鸡胚心房细胞切下的斑块的细胞内表面。单通道电流测量出乎意料地表明，β-γ 而非 α 亚基负责激活毒蕈碱门控钾通道。
Subunits of guanine nucleotide regulatory proteins purified from bovine cerebral cortex were used to perfuse the intracellular surface of excised patches of chick embryonic atrial cells. Single-channel current measurements unexpectedly indicate that the beta gamma, and not the alpha subunits, are responsible for activating the muscarinic-gated potassium channel.