Unloading the Stenotic Path to Identifying Medical Therapy for Calcific Aortic Valve Disease: Barriers and Opportunities.
Unloading the Stenotic Path to Identifying Medical Therapy for Calcific Aortic Valve Disease: Barriers and Opportunities.
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DOI：
10.1161/circulationaha.120.052531
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发表时间：
2021-04-13
期刊：
影响因子：
37.8
通讯作者：
Merryman WD
中科院分区：
文献类型：
--
作者：
Lindman BR;Merryman WD
早期CAVD患者可能从针对瓣膜病理的药物治疗中获益最多。目前，CAVD的检测依赖于听诊、症状发作或因其他原因偶然发现CAVD的超声心动图。由于听诊检测AS的敏感性和特异性较差，并且在阻塞严重之前没有AS相关症状，如果要有效地招募药物治疗试验并广泛应用有效的治疗方法，则迫切需要创新方法来筛选和检测早期CAVD。
Patients with earlier-stage CAVD are the ones likely to benefit most from medical therapy targeting the valve pathology. At present, detection of CAVD relies on auscultation, symptom onset, or an echocardiogram done for other reasons fortuitously revealing CAVD. Given the poor sensitivity and specificity of auscultation for detecting AS and the absence of AS-related symptoms until obstruction is severe, there is a pressing need for innovative ways to screen for and detect early-stage CAVD if trials of medical therapy are to be efficiently enrolled and therapies shown to be effective broadly applied.