Percutaneous penetration of methyl nicotinate at three anatomic sites: evidence for an appendageal contribution to transport?
Percutaneous penetration of methyl nicotinate at three anatomic sites: evidence for an appendageal contribution to transport?
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烟酸甲酯在三个解剖部位的经皮渗透：附肢对运输贡献的证据？
DOI：
10.1159/000210956
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Guy,RH
中科院分区：
文献类型：
--
作者：
Tur,E;Maibach,HI;Guy,RH
采用激光多普勒血流仪（LDF）技术，在人体志愿者的三个解剖部位（前额、前臂和手掌）评价了血管扩张剂烟酸甲酯（MN）的经皮吸收。实验设计用于检验皮肤渗透的动力学和程度取决于应用部位附件密度的假设。LDF技术测量了一旦化学品渗透到微血管系统，局部应用MN引起的皮肤血流量增加。在三个站点测得的LDF响应的显着差异被发现，进一步分析的数据表明，MN渗透是最大的通过前额皮肤，至少通过手掌和中间的皮肤前臂。因此，表观MN吸收和附件密度之间存在相关性。
Percutaneous absorption of the vasodilator methyl nicotinate (MN) was evaluated in human volunteers at three anatomic sites (forehead, forearm and palm) using the technique of laser Doppler flowmetry (LDF). The experiments were designed to test the hypothesis that the kinetics and extent of skin penetration are dependent upon the appendageal density at the site of application. The LDF technique measured the increase in skin blood flow elicited by topically applied MN once the chemical had penetrated to the microvasculature. Significant differences in the measured LDF responses at the three sites were found, and further analysis of the data suggested that MN penetration was greatest through forehead skin, least through the palm and intermediate across the skin of the forearm. A correlation therefore existed between apparent MN absorption and appendageal density.