The constitution of protoplasm
The constitution of protoplasm
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DOI：
10.1126/science.97.2525.451
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发表时间：
1943-05-21
期刊：
影响因子：
56.9
通讯作者：
Claude, A.
中科院分区：
文献类型：
--
作者：
Claude, A.
通过差速离心机械分离正常和肿瘤细胞。从细胞核和细胞质中获得纯化组分，包括分泌颗粒和暂时称为微粒体的小颗粒。对它们的来源、性质和性质进行了探讨。分泌颗粒和微粒体的化学成分相似，提示其来源相关。线粒体可能主要代表成熟的sec。颗粒。微粒体和sec.发现颗粒含有核糖核酸。这些细胞质成分，像其他含核酸的结构一样，可能具有自我复制的特性。
Normal and tumor cells were mechanically fractionated by differential centrifugation. Purified fractions were obtained from nuclei and cytoplasm, including secretory granules, and small particles provisionally called microsomes. Their origins, nature and properties were detd. Secretory granules and microsomes are chem. similar, suggesting related origins. Mitochondria may largely represent mature sec. granules. Microsomes and sec. granules were found to contain ribonucleic acid. These cytoplasmic components, like other nucleic acid-containing structures, may be endowed with the property of self-duplication.