Adiponectin multimers, body weight and markers of cardiovascular risk in adolescence: Northern Ireland Young Hearts Project
Adiponectin multimers, body weight and markers of cardiovascular risk in adolescence: Northern Ireland Young Hearts Project
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DOI：
10.1038/ijo.2012.214
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发表时间：
2013-09-01
影响因子：
4.9
通讯作者：
McKinley, M. C.
中科院分区：
文献类型：
--
作者：
McCourt, H. J.;Hunter, S. J.;McKinley, M. C.
背景：关于脂联素（AN）亚型、体重和心血管（CV）危险因素之间关系的研究是有限的，特别是在年轻人群中。目的：探讨青少年AN亚型与CV危险因素之间的相互关系，以及它们对体重状况的依赖性。设计：对92名肥胖、92名超重和92名正常体重、年龄和性别匹配的青少年的血液样本进行传统心血管疾病（CVD）风险生物标志物以及总、高分子量（HMW）、中、低分子量（LMW） AN的分析。结果：总HMW AN与腰臀比（P = 0.015, P = 0.006）、甘油三酯（P = 0.003, P = 0.003）、收缩压（P = 0.012, P = 0.024）呈显著负相关，与高密度脂蛋白（P = 0.024）呈显著正相关
BACKGROUND: Research examining the relationship between adiponectin (AN) isoforms, body weight and cardiovascular (CV) risk factors is limited, particularly in younger populations.OBJECTIVES: To investigate the inter-relationships between AN isoforms and CV risk factors, and their dependence on body weight status, in adolescents.DESIGN: Blood samples from 92 obese, 92 overweight and 92 normal weight age-and sex-matched adolescents were analysed for traditional cardiovascular disease (CVD) risk biomarkers and also total, high molecular weight (HMW), medium and low molecular weight (LMW) AN.RESULTS: A significant inverse association was observed between total and HMW AN and waist-hip ratio (P = 0.015, P = 0.006, respectively), triglycerides (P = 0.003, P = 0.003, respectively) and systolic blood pressure (P = 0.012, P = 0.024, respectively) and a significant positive association with high-density lipoprotein (P