Treatment with modafinil and escitalopram, alone and in combination, on cocaine-induced effects: a randomized, double blind, placebo-controlled human laboratory study.
Treatment with modafinil and escitalopram, alone and in combination, on cocaine-induced effects: a randomized, double blind, placebo-controlled human laboratory study.
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DOI：
10.1016/j.drugalcdep.2014.05.008
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发表时间：
2014-08-01
影响因子：
4.2
通讯作者：
De La Garza, Richard, II
中科院分区：
文献类型：
--
作者：
Verrico, Christopher D.;Haile, Colin N.;Mahoney, James J., III;Thompson-Lake, Daisy G. Y.;Newton, Thomas F.;De La Garza, Richard, II
同时给予多巴胺和5-羟色胺再摄取抑制剂可减少猴子的可卡因自我给药。与此一致的是，仅评估莫达非尼和选择性5-羟色胺再摄取抑制剂的临床试验就显示出作为可卡因依赖潜在药物疗法的一些有效性。我们假设，与单独使用莫达非尼相比，莫达非尼与埃西妥普兰联合使用将在更大程度上减弱可卡因的快感效应。在一项随机、双盲、平行分组设计中，参与者接受安慰剂(0毫克/天；n=16)、莫达非尼(200毫克/天；n=16)、艾司匹兰(20毫克/天；n=17)或莫达非尼+艾司他普兰(200+20毫克/天；n=15)治疗5天。在第5天，参与者在不同的疗程中接受了静脉注射可卡因(0或20毫克；随机)和5张1美元钞票。参与者对输液的主观效果进行了评级，随后做出了选择，要么返还1美元接受另一次输液，要么保留1美元不接受输液。与生理盐水相比，可卡因(20毫克)显著提高了大多数评分(p≤0.008)，包括“良好效果”、“刺激”和“兴奋”。与安慰剂相比，莫达非尼显著(p≤0.007)减弱了受试者对可卡因产生的“任何药物效应”、“高”、“好效应”和“刺激”的增加。与生理盐水相比，参与者选择可卡因输注的次数要多得多；然而，没有任何治疗方法显著减少了可卡因输注的选择。依西替普兰并未增强莫达非尼的疗效以减少任何措施。莫达非尼减弱了可卡因产生的许多积极的主观效应；然而，艾司西妥普兰与莫达非尼联合应用并不能增强莫达非尼减少可卡因效应的疗效。
Concurrent administration of dopamine and serotonin reuptake inhibitors reduces cocaine self-administration in monkeys. Consonant with this, clinical trials assessing modafinil and selective serotonin reuptake inhibitors alone show some efficacy as potential pharmacotherapies for cocaine dependence. We hypothesized that combining modafinil with escitalopram would attenuate the euphoric effects of cocaine to a greater degree than modafinil alone. In a randomized, double blind, parallel groups design participants received either placebo (0 mg/day; n = 16), modafinil (200 mg/day; n = 16), escitalopram (20 mg/day; n = 17), or modafinil+escitalopram (200+20 mg/day; n = 15) for 5 days. On day 5, during separate sessions participants received an intravenous sample of cocaine (0 or 20mg; randomized) and five $1 bills. Participants rated the subjective effects of the infusions and subsequently made choices to either return $1 and receive another infusion or keep $1 and receive no infusion. Compared to saline, cocaine (20mg) significantly (p ≤ 0.008) increased most ratings, including “Good Effects”, “Stimulated”, and “High”. Relative to placebo, modafinil significantly (p ≤ 0.007) attenuated subject-rated increases of “Any Drug Effect”, “High”, “Good Effects”, and “Stimulated” produced by cocaine. Compared to saline, participants chose cocaine infusions significantly more; however, no treatment significantly reduced choices for cocaine infusions. Escitalopram did not enhance the efficacy of modafinil to reduce any measure. Modafinil attenuated many positive subjective effects produced by cocaine; however, escitalopram combined with modafinil did not enhance the efficacy of modafinil to reduce cocaine effects.
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影响因子：
3.4
作者：
Andersen, Monica L.;Kessler, Eileen;Murnane, Kevin S.;McClung, Jessica C.;Tufik, Sergio;Howell, Leonard L.
通讯作者：
Howell, Leonard L.
DOI：
10.1124/jpet.106.106583
发表时间：
2006-11-01
影响因子：
3.5
作者：
Madras, Bertha K.;Xie, Zhihua;Fischman, Alan J.
通讯作者：
Fischman, Alan J.
影响因子：
4.7
作者：
Kalechstein, A. D.;Mahoney, J. J., III;De La Garza, R., II
通讯作者：
De La Garza, R., II
影响因子：
4.4
作者：
Grabowski, J;Shearer, J;Negus, SS
通讯作者：
Negus, SS
影响因子：
2.3
作者：
Howell, Leonard L.
通讯作者：
Howell, Leonard L.