In situ nanochemical imaging of label-free drugs: a case study of antimalarials in Plasmodium falciparum-infected erythrocytes
In situ nanochemical imaging of label-free drugs: a case study of antimalarials in Plasmodium falciparum-infected erythrocytes
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DOI：
10.1039/c1cc16211j
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发表时间：
2012-01-21
影响因子：
4.9
通讯作者：
Biot, Christophe
中科院分区：
文献类型：
--
作者：
Dubar, Faustine;Bohic, Sylvain;Biot, Christophe
我们在这里报告的第一次在体外定位的未标记的抗疟药物具有高空间分辨率。这一战略进一步提高了我们对抗疟药物作用机制的认识。我们的方法可以应用于广泛的领域，其中在亚细胞水平上的药物的定量化学成像显得至关重要。
We report here for the first time the in vitro localization of unlabeled antimalarial drugs with high spatial resolution. This strategy further enhances our understanding of the action mechanisms of antimalarial drugs. Our approach may be applied to a wide range of domains where quantitative chemical imaging of drugs at the sub-cellular level appears critical.