Golgi protein 73 activation of MMP-13 promotes hepatocellular carcinoma cell invasion.
Golgi protein 73 activation of MMP-13 promotes hepatocellular carcinoma cell invasion.
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高尔基体蛋白73激活MMP-13促进肝癌细胞侵袭
DOI：
10.18632/oncotarget.5590
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发表时间：
2015-10-20
期刊：
影响因子：
--
通讯作者：
Zhang H
中科院分区：
文献类型：
--
作者：
Jin D;Tao J;Li D;Wang Y;Li L;Hu Z;Zhou Z;Chang X;Qu C;Zhang H
高尔基体蛋白73（GP 73）是肝细胞癌（HCC）的血清标志物，但其在HCC中的作用尚不清楚。我们报道GP 73通过上调基质金属蛋白酶-13（MMP-13）促进细胞侵袭，这是恶性肿瘤的标志。GP 73通过cAMP反应元件结合蛋白（CREB）介导的转录激活增强MMP-13表达。GP 73和MMP-13的水平在人HCC组织中增加并且正相关。增强的MMP-13增强HCC细胞转移。因此，GP 73-CREB-MMP-13轴增强癌细胞侵袭，并且可能是HCC治疗的靶点。
Golgi Protein 73 (GP73) is a serum biomarker for hepatocellular carcinoma (HCC), however its role in HCC is not clear. We report that GP73 promotes cell invasion, the hallmark of malignancy, through the upregulation of matrix metalloproteinase-13 (MMP-13). GP73 enhances MMP-13 expression through cAMP responsive element binding protein (CREB)-mediated transcription activation. Levels of GP73 and MMP-13 are increased and positively correlated in human HCC tissues. Augmented MMP-13 potentiates HCC cell metastasis. Thus, the GP73-CREB-MMP-13 axis potentiates cancer cell invasion and may be a target for HCC treatment.