ACTIVITY OF LUNG IRRITANT RECEPTORS IN PULMONARY MICROEMBOLISM, ANAPHYLAXIS AND DRUG-INDUCED BRONCHOCONSTRICTIONS
ACTIVITY OF LUNG IRRITANT RECEPTORS IN PULMONARY MICROEMBOLISM, ANAPHYLAXIS AND DRUG-INDUCED BRONCHOCONSTRICTIONS
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DOI：
10.1113/jphysiol.1969.sp008867
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发表时间：
1969-01-01
影响因子：
5.5
通讯作者：
WIDDICOMBE, JG
中科院分区：
文献类型：
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作者：
MILLS, JE;SELLICK, H;WIDDICOMBE, JG
1.用记录单个迷走神经纤维动作电位的方法研究了家兔肺刺激性受体。部分家兔双侧迷走神经切断，部分家兔麻痹并人工通气.感受器在肺的充气和放气时迅速适应不规则放电。许多人是通过向肺部吹入氨蒸气来刺激的，有些人是通过将细导管插入右支气管树来刺激的。纤维的传导速度在3.6 - 25.8米/秒的范围内。静脉注射磷酸组胺（25-100 μg/kg）可强烈刺激受体。之前注射异丙肾上腺素也降低了组胺引起的支气管收缩，显著降低了反应。通过静脉注射异丙肾上腺素、苯基双胍和微栓子以及在先前对卵蛋白致敏的家兔中诱导的过敏反应刺激受体。5.受体反应的大小与肺总阻力、肺顺应性、潮气量或呼吸频率的同时变化不密切相关.可以得出结论，在兔与完整的迷走神经，肺刺激受体有助于反射性呼吸亢进和支气管收缩的条件下研究。
1. Lung irritant receptors have been studied in rabbits by recording action potentials from single vagal nerve fibres. Some of the rabbits were bilaterally vagotomized, and some paralysed and artificially ventilated.2. The receptors gave rapidly adapting irregular discharges on inflation and deflation of the lungs. Many were stimulated by insufflation of ammonia vapour into the lungs, and some by passage of a fine catheter into the right bronchial tree. The fibres had conduction velocities in the range 3·6–25·8 m/sec.3. The receptors were strongly stimulated by intravenous injections of histamine acid phosphate, 25–100 μg/kg. The response was considerably reduced by previous injection of isoprenaline which also reduced the bronchoconstriction due to histamine.4. The receptors were stimulated by intravenous injections of isoprenaline, phenyl diguanide and micro‐emboli, and by anaphylaxis induced in rabbits previously sensitized to egg albumin.5. The receptor responses could not be closely correlated in size with simultaneous changes in total lung resistance, lung compliance, tidal volume or breathing frequency.6. It is concluded that, in rabbits with intact vagus nerves, lung irritant receptors contribute to the reflex hyperpnoea and bronchoconstriction of the conditions studied.