Cognitive impairment and functional outcome in schizophrenia and bipolar disorder
Cognitive impairment and functional outcome in schizophrenia and bipolar disorder
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DOI：
10.4088/jcp.1006e12
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发表时间：
2006-01-01
影响因子：
5.3
通讯作者：
Green, Michael F.
中科院分区：
文献类型：
--
作者：
Green, Michael F.
大量证据支持精神分裂症患者认知障碍与功能结局之间的关系。认知障碍被认为是精神分裂症的一个核心特征，包括处理速度、注意力/警觉性、工作记忆、语言学习、视觉学习、推理和解决问题以及社会认知方面的问题。在遗传学研究中，这些缺陷也可以作为该病的一种内表型。认知被认为是精神分裂症患者合理的治疗目标，部分原因是认知缺陷导致功能结果较差。同样，开始有证据表明，认知障碍也可能是双相情感障碍的一个核心特征。此外，认知缺陷会对双相情感障碍患者的功能结果产生不利影响。这一证据表明，认知可以被认为是对精神分裂症和双相情感障碍进行干预的合理目标。
A considerable amount of evidence supports the relationship between cognitive impairment and functional outcomes in schizophrenia. Cognitive impairment is considered a core feature of schizophrenia that includes problems in speed of processing, attention/vigilance, working memory, verbal learning, visual learning, reasoning and problem solving, and social cognition. These deficits can also serve as an endophenotype for the illness in studies of genetics. Cognition is considered a reasonable treatment target in individuals with schizophrenia, partly because cognitive deficits contribute to poor functional outcomes. Similarly, evidence is beginning to emerge that cognitive impairment may also be a core feature of bipolar disorder. In addition, cognitive deficits adversely affect functional outcomes in bipolar disorder. This evidence suggests that cognition can be considered a reasonable target for intervention in both schizophrenia and bipolar disorder.