Cholinergic influences on estrogen-dependent sexual behavior in female rats.
Cholinergic influences on estrogen-dependent sexual behavior in female rats.
复制标题
胆碱能对雌性大鼠雌激素依赖性性行为的影响。
DOI：
10.1037/h0077837
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Witcher,JA
中科院分区：
文献类型：
--
作者：
Clemens,LG;Dohanich,GP;Witcher,JA
Examined the ability of cholinergic agents to influence hormone-dependent sexual behavior in Sherman rats. In Exp I, sexual behavior, indicated by the incidence of lordosis, was significantly increased in estrogen-treated Ss following bilateral infusion of a cholinergic receptor agonist, carbachol (. 5 μg/cannula) into the medial preoptic area of the brain. Infusion of an artificial cerebrospinal fluid vehicle failed to facilitate lordosis. The incidence of lordosis was normally highest 15 min after carbachol infusion began to wane by 45 min, and had returned to control levels by 90 min. Centrally administered carbachol activated lordosis at lower levels of estrogen priming than did systemically administered progesterone. In Exp II, Ss brought into sexual receptivity by administration of estrogen and progesterone received preoptic infusions of an acetylcholine synthesis inhibitor, hemicholinium-3 (HC-3). Significant reductions in the incidence of lordosis were observed following bilateral infusion of HC-3 (1.25 μg/cannula). This inhibition of lordosis was prevented when carbachol (. 5 μg/cannula) was infused along with HC-3. Results confirm the importance of cholinergic influences on sexual behavior in female rats.(20 ref)(PsycINFO Database Record (c) 2016 APA, all rights reserved)
