CENTRAL CONTROL OF SONG IN CANARY, SERINUS-CANARIUS
CENTRAL CONTROL OF SONG IN CANARY, SERINUS-CANARIUS
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DOI：
10.1002/cne.901650405
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发表时间：
1976-01-01
影响因子：
2.5
通讯作者：
LEONARD, CM
中科院分区：
文献类型：
--
作者：
NOTTEBOHM, F;STOKES, TM;LEONARD, CM
通过结合行为和解剖技术，追踪了金丝雀控制鸟鸣的中枢神经通路。对成年雄性金丝雀进行单侧电解脑损伤，其鸣叫声先前已被记录并用声谱仪进行分析。经过几天的术后记录后，将这些鸟处死，并用 Fink-Heimer 技术对它们的大脑进行组织学处理以进行变性染色。尽管新纹状体和头侧上纹状体的大损伤对鸣叫没有影响，但尾侧上纹状体腹侧（HVc）离散大细胞区域受损后出现严重的鸣叫缺陷。退化纤维从该区域追踪到前脑中另外 2 个离散的核：一个位于嗅觉叶（X 区，泪滴状小细胞核），另一个位于古纹状体 (RA) 中的圆形大细胞核。 X单侧病变对歌曲无影响； RA 病变导致严重的歌曲缺陷。 RA 的退化纤维加入枕中脑束，并广泛向同侧投射至丘脑、中脑丘间核、网状结构和髓质。发现了与支配鸣管（歌曲产生器官）的运动核细胞的直接连接。丘间核的单侧病变（之前与发声行为的控制有关）对歌曲影响不大。 HVc 的双侧病变导致永久性（9 个月）完全消除鸣叫的可听成分，尽管鸟采取了鸣叫的典型姿势和动作。左半球的损伤似乎比右半球的损伤导致更大的缺陷。金丝雀大脑中可能存在声音控制的定位，其上层的左半球占主导地位。
Central nervous pathways controlling bird song in the canary were traced using a combination of behavioral and anatomical techniques. Unilateral electrolytic brain lesions were made in adult male canaries whose song had been previously recorded and analyzed on a sound sepctrograph. After several days of postoperative recording the birds were sacrificed and their brains processed histologically for degeneration staining with the Fink-Heimer technique. Although large lesions in the neostriatum and rostral hyperstriatum had no effect on song, severe song deficits followed damage to a discrete large-celled area in the caudal hyperstriatum ventrale (HVc). Degenerating fibers were traced from this region to 2 other discrete nuclei in the forebrain: one in the parolfactory lobe (area X, a teardropshaped small-celled nucleus), and a round large-celled nucleus in the archistriatum (RA). Unilateral lesions of X had no effect on song; lesions of RA caused severe song deficits. Degenerating fibers from RA joined the occipitomesencephalic tract and had widespread ipsilateral projections to the thalamus, nucleus intercollicularis of the midbrain, reticular formation and medualla. Direct connections were found onto the cells of the motor nucleus innervating the syrinx, the organ of song production. Unilateral lesions of nucleus intercollicularis (previously implicated in the control of vocal behavior) had little effect on song. One bilateral lesion of HVc resulted in permanent (9 mo.) and complete elimination of the audible components of song, although the bird assumed the posture and movements typical of song. Lesions of the left hemisphere appeared to result in greater deficits than lesions of the right one. There may be a localization of vocal control in the canary brain with an overlying left hemispheric dominance.