New views on the selection acting on genetic polymorphism in central metabolic genes.
New views on the selection acting on genetic polymorphism in central metabolic genes.
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DOI：
10.1111/nyas.13285
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发表时间：
2017-02
影响因子：
5.2
通讯作者：
Eanes WF
中科院分区：
文献类型：
--
作者：
Eanes WF
中心代谢基因多态性作为自然种群适合度变异的一个来源的研究可以追溯到20世纪60年代等位酶的发现。这些基因及其酶的独特功能和我们的知识库极大地便利了这一群体的系统水平研究。期望的途径通量控制是理解基因的分子进化的核心进行了讨论，以及研究，试图把基因特异性的分子进化和多态性的途径和网络架构的背景下。有一个越来越复杂的图片的代谢基因承担额外的作用超出了他们的教科书合成代谢和分解代谢反应。特别是，这篇评论强调了这些基因作为能量感应机制的一部分的潜在作用。强调细胞关键代谢物的浓度是细胞能量状态和营养输入的反映。这些代谢物是自上而下的信号传递者，通过参与能源经济的信号通路来设置信号。我建议，在中央代谢基因的多态性转移代谢物的浓度，并在这种方式作为遗传修饰剂的能量状态耦合到转录网络，影响生理权衡与显着的健身后果。
Studies of the polymorphism of central metabolic genes as a source of fitness variation in natural populations date back to the discovery of allozymes in the 1960s. The unique features of these genes and their enzymes and our knowledge base greatly facilities the systems-level study of this group. The expectation that pathway flux control is central to understanding the molecular evolution of genes is discussed, as well as studies that attempt to place gene-specific molecular evolution and polymorphism into a context of pathway and network architecture. There is an increasingly complex picture of the metabolic genes assuming additional roles beyond their textbook anabolic and catabolic reactions. In particular, this review emphasizes the potential role of these genes as part of the energy-sensing machinery. It is underscored that the concentrations of key cellular metabolites are the reflections of cellular energy status and nutritional input. These metabolites are the top-down signaling messengers that set signaling through signaling pathways that are involved in energy economy. I propose that the polymorphisms in central metabolic genes shift metabolite concentrations and in that fashion act as genetic modifiers of the energy-state coupling to the transcriptional networks that affect physiological trade-offs with significant fitness consequences.