PROBLEMS IN PLETHYSMOGRAPHIC ASSESSMENT OF CHANGES IN TOTAL LUNG CAPACITY IN ASTHMA
PROBLEMS IN PLETHYSMOGRAPHIC ASSESSMENT OF CHANGES IN TOTAL LUNG CAPACITY IN ASTHMA
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DOI：
10.1164/arrd.1978.118.4.685
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发表时间：
1978-01-01
期刊：
影响因子：
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通讯作者：
MCFADDEN, ER
中科院分区：
文献类型：
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作者：
BROWN, R;INGRAM, RH;MCFADDEN, ER
本文研究了哮喘患者在诱发支气管痉挛治疗前、中、后腹部气体加压对肺容积描记法测定的肺总容量（TLC）的影响。TLC由接近残气量、功能残气量和接近TLC的喘息动作推导而成。在支气管痉挛期间，这些衍生TLC值之间的显著差异显著增加。TLC是否出现增加，以及增加多少，取决于其来源的肺活量水平。在支气管痉挛期间TLC的个体增加不能用腹部气体量的增加或在喘息期间压缩和减压的程度来解释。在博伊尔定律喘息动作期间，胸膜和肺泡的压力波动可能是不均匀的，并且在由闭合气道对着的肺区域上比在与嘴连通的区域上更大。这将导致低估在口腔测量的肺泡压力波动和高估胸腔气体容量，并在很大程度上解释了观察到的哮喘TLC值之间差异的增加以及TLC表观变化对进行喘息动作时VC [肺活量]水平的依赖性。
The effect of abdominal gas compression on plethysmographically determined total lung capacity (TLC) was studied in asthmatic patients before, during and after treatment of induced bronchospasm. TLC was derived from panting maneuvers near residual volume, at functional residual capacity and near TLC. Significant differences among these derived TLC values increased significantly during bronchospasm. Whether or not TLC appeared to increase, and by how much, depended on the level of the vital capacity from which it was derived. Individual increases in TLC during bronchospasm could not be explained by increases in abdominal gas volume or in the extent to which it was compressed and decompressed during panting. During the Boyle''s Law panting maneuver, pleural and alveolar, pressure swings possibly are nonhomogeneous and greater over lung regions subtended by closed airways than over regions in communication with the mouth. This would result in an underestimation of alveolar pressure swings as measured at the mouth and an overestimation of thoracic gas volume, and would account in large part for the observed increase in discrepancies between the derived TLC values in asthma as well as the dependence of apparent TLC changes on the level of the VC [vital capacity] at which the panting maneuver is performed.