Colorectal cancer incidence in Asian populations in California: effect of nativity and neighborhood-level factors.
Colorectal cancer incidence in Asian populations in California: effect of nativity and neighborhood-level factors.
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DOI：
10.1038/ajg.2013.488
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发表时间：
2014-04
期刊：
影响因子：
--
通讯作者：
Gomez SL
中科院分区：
文献类型：
--
作者：
Ladabaum U;Clarke CA;Press DJ;Mannalithara A;Myer PA;Cheng I;Gomez SL
遗传和环境因素可能导致不同人群中结直肠癌（CRC）发病率的差异。我们利用加州癌症登记处（CCR）的资源和加州多样化的亚洲人群进行了一项队列研究，探讨亚洲亚组中CRC发病率、出生地和社区水平因素之间的关系。我们确定了1990年至2004年CCR中的CRC病例，并计算了非西班牙裔白人和美国出生与外国出生的亚洲种族亚组的年龄调整CRC发病率，按社区社会经济地位（SES）和“种族飞地”分层。通过连接点分析研究了趋势。在外国出生的南亚人中CRC发病率最低（22.0/100，000; 95%置信区间（CI）：19.7-24.5/100，000），在外国出生的日本人中最高（74.6/100，000; 95% CI：70.1-79.2/100，000）。除日本人外，所有亚洲亚组中的女性以及除日本人和美国出生的中国人外的所有亚洲亚组中的男性的CRC发病率均低于非西班牙裔白人。在中国男性和菲律宾女性和男性中，外国出生的CRC发病率低于美国出生的人;日本女性和男性的情况正好相反。在非西班牙裔白人中，而不是大多数亚洲亚组，CRC发病率随时间推移而下降。CRC发病率与非西班牙裔白人的社区SES和亚洲人的种族飞地水平呈负相关。在加州，不同亚裔亚组的CRC发病率差异很大。CRC发病率和出生和居住在一个民族飞地之间的显着关联表明后天环境因素的实质性影响。在我们的研究期间，大多数亚洲人的CRC发病率没有下降，这可能表明与白人相比，筛查存在差异。
Heritable and environmental factors may contribute to differences in colorectal cancer (CRC) incidence across populations. We capitalized on the resources of the California Cancer Registry (CCR) and California’s diverse Asian population to perform a cohort study exploring the relationships between CRC incidence, nativity, and neighborhood-level factors across Asian subgroups. We identified CRC cases in the CCR from 1990 to 2004 and calculated age-adjusted CRC incidence rates for non-Hispanic Whites and US-born vs. foreign-born Asian ethnic subgroups, stratified by neighborhood socioeconomic status (SES) and “ethnic enclave.” Trends were studied with joinpoint analysis. CRC incidence was lowest among foreign-born South Asians (22.0/100,000; 95% confidence interval (CI): 19.7–24.5/100,000) and highest among foreign-born Japanese (74.6/100,000; 95% CI: 70.1–79.2/100,000). Women in all Asian subgroups except Japanese, and men in all Asian subgroups except Japanese and US-born Chinese, had lower CRC incidence than non-Hispanic Whites. Among Chinese men and Filipino women and men, CRC incidence was lower among foreign-born than US-born persons; the opposite was observed for Japanese women and men. Among non-Hispanic Whites, but not most Asian subgroups, CRC incidence decreased over time. CRC incidence was inversely associated with neighborhood SES among non-Hispanic Whites, and level of ethnic enclave among Asians. CRC incidence rates differ substantially across Asian subgroups in California. The significant associations between CRC incidence and nativity and residence in an ethnic enclave suggest a substantial effect of acquired environmental factors. The absence of declines in CRC incidence rates among most Asians during our study period may point to disparities in screening compared with Whites.
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影响因子：
12.7
作者：
Gomez SL;Quach T;Horn-Ross PL;Pham JT;Cockburn M;Chang ET;Keegan TH;Glaser SL;Clarke CA
通讯作者：
Clarke CA
影响因子：
2.3
作者：
Giddings, Brenda Hofer;Kwong, Sandy L.;Snipes, Kurt P.
通讯作者：
Snipes, Kurt P.
影响因子：
45.3
作者：
Baxter, Nancy N.;Warren, Joan L.;Doria-Rose, V. Paul
通讯作者：
Doria-Rose, V. Paul
DOI：
10.1158/1055-9965.epi-10-0021
发表时间：
2010-05
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Keegan TH;John EM;Fish KM;Alfaro-Velcamp T;Clarke CA;Gomez SL
通讯作者：
Gomez SL
影响因子：
12.7
作者：
Gomez, SL;Kelsey, JL;Sidney, S
通讯作者：
Sidney, S