Endocrine determinants of fertility: serum androgen concentrations during follow-up of adolescents into the third decade of life.
Endocrine determinants of fertility: serum androgen concentrations during follow-up of adolescents into the third decade of life.
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生育力的内分泌决定因素：青少年至三十岁随访期间的血清雄激素浓度。
DOI：
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发表时间：
1990
影响因子：
5.8
通讯作者：
R. Vihko
中科院分区：
文献类型：
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作者：
D. Apter;R. Vihko
我们已经完成了一项为期13年的纵向研究的内分泌功能的女性最初年龄在7-17岁，现在报告的因素有关的生育能力，在这些妇女，主要是血清睾酮（T）和雄烯二酮（A）浓度与怀孕。经年龄效应校正的纵向回归分析显示，目前血清T和A浓度与12年前测量的浓度相关（T：r = 0.47，P <0.01; A：r = 0.57，P <0.001）。未怀孕的妇女在怀孕前的血清T和A浓度高于怀孕妇女（T：从未妊娠，平均值+/- SEM，1.10 +/- 0.06 nmol/L，妊娠0.81 +/- 0.07 nmol/L，P = 0.004; A：从未怀孕4.00 +/- 0.28 nmol/L，怀孕2.98 +/- 0.33 nmol/L，P = 0.03）。血清雄激素浓度与反映性行为和口服避孕药使用的变量无关。因此，这些数据表明，青少年血清雄激素浓度保留到成年，并反映在生育模式在第三个十年的生活。较高的血清雄激素浓度与较低的生育力有关。与我们以前的研究结果一起，这些数据表明，青春期形成的内分泌特征似乎至少持续到30岁。
We have completed a 13-yr longitudinal study of endocrine features in females originally aged 7-17 yr and report now factors related to fertility in these women, mainly serum testosterone (T) and androstenedione (A) concentrations in relation to becoming pregnant. Longitudinal regression analysis, corrected for the effect of age, showed that current serum T and A concentrations are correlated with those measured 12 yr earlier (T: r = 0.47, P less than 0.01; A: r = 0.57, P less than 0.001). Age-adjusted serum T and A concentrations before any pregnancies were higher in women who subsequently had no pregnancies than in those who had been pregnant (T: never pregnant, mean +/- SEM, 1.10 +/- 0.06 nmol/L, pregnant 0.81 +/- 0.07 nmol/L, P = 0.004; A: never pregnant 4.00 +/- 0.28 nmol/L, pregnant 2.98 +/- 0.33 nmol/L, P = 0.03). Serum androgen concentrations were not related to variables reflecting sexual behavior and the use of oral contraception. The data therefore show that adolescent serum androgen concentrations are preserved into adulthood and are reflected in fertility patterns during the third decade of life. Higher serum androgen concentrations are associated with lower fertility. Together with our previous findings, these data demonstrate that endocrine characteristics formed during puberty seem to persist at least until 30 yr of age.