Longitudinal association between early atopic dermatitis and subsequent attention-deficit or autistic disorder: A population-based case-control study.
Longitudinal association between early atopic dermatitis and subsequent attention-deficit or autistic disorder: A population-based case-control study.
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早期特应性皮炎与随后的注意缺陷或自闭症疾病之间的纵向关联：基于人群的病例对照研究。
DOI：
10.1097/md.0000000000005005
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发表时间：
2016-09
期刊：
影响因子：
1.6
通讯作者：
Su TP
中科院分区：
文献类型：
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作者：
Lee CY;Chen MH;Jeng MJ;Hsu JW;Tsai SJ;Bai YM;Hung GY;Yen HJ;Chen TJ;Su TP
特应性皮炎是儿童常见的过敏性疾病之一。过敏性疾病的存在被发现与儿童发生注意力缺陷多动障碍（ADHD）或自闭症谱系障碍（ASD）的风险有关，但目前尚无定论。本研究旨在探讨儿童期AD与儿童后期ADHD或ASD的纵向关系。从台湾全民健康保险研究数据库中检索1998年至2008年出生并在3岁以下和1个月以上诊断为AD的幼儿。年龄和性别匹配的无终身AD的幼儿作为对照组。所有登记的幼儿都被跟踪到2011年，以确定ADHD或ASD的发展。采用多因素考克斯回归分析方法分析其风险比。分析与过敏性合并症相关的风险。共有18,473名幼儿被纳入AD组。当年龄在3岁或以上时，AD的存在显著增加了患ADHD（HR = 2.92，95%置信区间[CI] = 2.48-3.45）或ASD（HR = 8.90，95% CI = 4.98-15.92）的风险。AD组中合并过敏性鼻炎、过敏性结膜炎和哮喘3种疾病的儿童发生ADHD和ASD的风险最大（ADHD：HR = 4.67，95%CI = 3.81-5.43; ASD：HR = 16.65，95%CI = 8.63-30.60）。总之，在3岁以下患有AD的幼儿在童年后期患ADHD和ASD的风险更高。照顾患有AD的幼儿的儿科医生应该了解在以后的生活中发展ADHD和ASD的风险增加，特别是当儿童患有某些合并症时，如过敏性鼻炎，过敏性结膜炎和哮喘。
Atopic dermatitis (AD) is one of the common allergic diseases in children. The presence of allergic diseases was found to have association with the risk of developing attention-deficit hyperactivity disorder (ADHD) or autistic spectrum disorder (ASD) in children, but it is still inconclusive. This study was to investigate the longitudinal relationship between AD developed during toddlerhood and subsequent development of ADHD or ASD in later childhood. Toddlers born between 1998 and 2008 and diagnosed with AD at the age younger than 3 years and older than 1 month were retrieved from Taiwan's National Health Insurance Research Database. Age- and gender-matched toddlers with no lifetime AD were enrolled as the control group. All enrolled toddlers were followed until 2011 to identify the development of ADHD or ASD. Multivariate Cox regression analysis was performed to analyze the hazard ratios (HRs). The risks associated with allergic comorbidities were analyzed. A total of 18,473 toddlers were enrolled into the AD group. The presence of AD significantly increased the risk of developing ADHD (HR = 2.92, 95% confidence interval [CI] = 2.48–3.45) or ASD (HR = 8.90, 95% CI = 4.98–15.92) when aged 3 years or older. Children from the AD group with 3 comorbidities together, namely, allergic rhinitis, allergic conjunctivitis, and asthma, had the greatest risk of developing ADHD and ASD (ADHD: HR = 4.67, 95% CI = 3.81–5.43; ASD: HR = 16.65, 95% CI = 8.63–30.60). In conclusion, toddlers who suffer from AD at the age younger than 3 years are at a higher risk of developing ADHD and ASD during later childhood. Pediatricians taking care of toddlers with AD should have knowledge of this increased risk of developing ADHD and ASD later in life, especially when children have certain comorbidities such as allergic rhinitis, allergic conjunctivitis, and asthma.
影响因子：
--
作者：
Suh DI;Koh YY
通讯作者：
Koh YY