Death of a child and the risk of heart failure: a population-based cohort study from Denmark and Sweden
Death of a child and the risk of heart failure: a population-based cohort study from Denmark and Sweden
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DOI：
10.1002/ejhf.2372
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发表时间：
2021-11-16
影响因子：
18.2
通讯作者：
Laszlo, Krisztina D.
中科院分区：
文献类型：
--
作者：
Wei, Dang;Li, Jiong;Laszlo, Krisztina D.
我们的目的是调查一个孩子的死亡，最严重的压力源之一，是否与心脏衰竭（HF）的风险相关。方法和结果我们进行了一项基于人群的队列研究，涉及1973-2016年和1973-2014年丹麦和瑞典医学出生登记册中记录的活产儿童的父母（n = 6 717 349）。我们从几个全国性的登记处检索了儿童死亡、HF诊断和父母的社会人口学特征的信息。我们进行泊松回归模型，以估计发病率比（IRR）和95%的置信区间（CI）的HF与丧亲之痛。共有129 829（1.9%）的父母失去了至少一个孩子在随访期间。失去亲人的父母发生心力衰竭的风险比没有失去亲人的父母高35%（IRR 1.35，95%CI 1.29-1.41; p
Aims We aimed to investigate whether the death of a child, one of the most severe stressors, is associated with the risk of heart failure (HF).Methods and results We conducted a population-based cohort study involving parents of live-born children recorded in the Danish and Swedish Medical Birth Registers during 1973-2016 and 1973-2014, respectively (n = 6 717 349). We retrieved information on child death, HF diagnosis and sociodemographic characteristics of the parents from several nationwide registries. We performed Poisson regression models to estimate incidence rate ratios (IRR) and 95% confidence intervals (CI) for HF in relation to bereavement. A total of 129 829 (1.9%) parents lost at least one child during the follow-up. Bereaved parents had a 35% higher risk of HF than the non-bereaved (IRR 1.35, 95% CI 1.29-1.41; p