Luminescence imaging of water irradiated by protons under FLASH radiation therapy conditions
Luminescence imaging of water irradiated by protons under FLASH radiation therapy conditions
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DOI：
10.1088/1361-6560/ace60b
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发表时间：
2023-08-07
影响因子：
3.5
通讯作者：
Yamamoto，Seiichi
中科院分区：
文献类型：
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作者：
Yogo，Katsunori;Kodaira，Satoshi;Yamamoto，Seiichi
目的超高剂量率（UHDR）FLASH放射治疗有可能减少对正常组织的损伤，同时保持抗肿瘤疗效。然而，对于质子束闪光放射治疗来说，快速、精确的剂量分布测量仍然很困难。为了解决这个问题，我们在使用电荷耦合器件相机捕获的 UHDR 质子束照射后对水进行了发光成像。方法我们使用来自回旋加速器的 60 MeV 质子束，剂量率为 0.03–837 Gy s−1。还测试了基于同步加速器的质子治疗系统发射的剂量率为 0.45–4320 Gy s−1 的治疗性 139.3 MeV 质子束。将 UHDR 光束引起的发光光强与传统光束产生的发光光强进行比较，以比较光强的剂量率依赖性及其分布。 主要结果在 UHDR 条件下，水的发光图像清晰可见，曝光时间明显短于传统光束。光强度与传递的剂量成线性比例，这与传统光束相似。对于 0.03–837 Gy s−1，没有观察到显着的剂量率依赖性。UHDR 光束的光强分布与传统光束的光强分布一致。加速器（同步加速器或回旋加速器）和束流能量之间的结果没有差异。意义使用 UHDR 质子束和传统束可以实现水的发光成像。所提出的方法应该适用于质子闪光治疗的快速、简单的质量保证调查，因为它有利于剂量分布的实时、无胶片测量，并且对于快速反馈很有用。
ObjectiveFLASH radiation therapy with ultrahigh dose rates (UHDR) has the potential to reduce damage to normal tissue while maintaining anti-tumor efficacy. However, rapid and precise dose distribution measurements remain difficult for FLASH radiation therapy with proton beams. To solve this problem, we performed luminescence imaging of water following irradiation by a UHDR proton beam captured using a charge-coupled device camera.ApproachWe used 60 MeV proton beams with dose rates of 0.03–837 Gy s− 1 from a cyclotron. Therapeutic 139.3 MeV proton beams with dose rates of 0.45–4320 Gy s− 1 delivered by a synchrotron-based proton therapy system were also tested. The luminescent light intensity induced by the UHDR beams was compared with that produced by conventional beams to compare the dose rate dependency of the light intensity and its profile.Main resultsLuminescence images of water were clearly visualized under UHDR conditions, with significantly shorter exposure times than those with conventional beams. The light intensity was linearly proportional to the delivered dose, which is similar to that of conventional beams. No significant dose-rate dependency was observed for 0.03–837 Gy s− 1. The light-intensity profiles of the UHDR beams agreed with those of conventional beams. The results did not differ between accelerators (synchrotron or cyclotron) and beam energies.SignificanceLuminescence imaging of water is achievable with UHDR proton beams as well as with conventional beams. The proposed method should be suitable for rapid and easy quality assurance investigations for proton FLASH therapy, because it facilitates real-time, filmless measurements of dose distributions, and is useful for rapid feedback.