Tumor dormancy and cancer stem cells: implications for the biology and treatment of breast cancer metastasis.
Tumor dormancy and cancer stem cells: implications for the biology and treatment of breast cancer metastasis.
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DOI：
10.3233/bd-2007-26108
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发表时间：
2006
期刊：
影响因子：
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通讯作者：
A. Allan;S. Vantyghem;A. Tuck;A. Chambers
中科院分区：
文献类型：
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作者：
A. Allan;S. Vantyghem;A. Tuck;A. Chambers
乳腺癌仍然是妇女发病率和死亡率的主要原因，主要是由于原发乳腺癌有向区域和远处转移的倾向。原发肿瘤切除后的转移扩散可能很难识别，这给患者带来了关于可能的癌症复发的不确定性。这在乳腺癌中是一个特别的问题，事实证明，在表面上几十年的无病生存之后，复发可能会发生。乳腺癌中肿瘤休眠的机制仍然知之甚少，这给乳腺癌的实验研究和临床治疗带来了巨大的挑战。该综述将讨论目前已知的转移过程和肿瘤休眠过程，考虑越来越多的证据表明肿瘤干细胞可能有助于肿瘤的进展和休眠，并推测这项研究的临床意义和意义。
Breast cancer remains a leading cause of morbidity and mortality in women, mainly due to the propensity of primary breast tumors to metastasize to regional and distant sites. Metastatic spread after the removal of a primary tumor can be difficult to identify, creating uncertainty in patients with regards to possible cancer recurrence. This is a particular problem in breast cancer, exemplified by the fact that recurrence can take place after decades of apparent disease-free survival. The mechanisms underlying tumor dormancy in breast cancer remain poorly understood, and this presents significant challenges to both experimental investigation and clinical management of breast cancer. This review will discuss what is currently known about the metastatic process and tumor dormancy, consider the growing evidence that cancer stem cells may contribute to tumor progression and dormancy, and speculate about the clinical importance and implications of this research.