Determinants of serum brain-derived neurotrophic factor
Determinants of serum brain-derived neurotrophic factor
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DOI：
10.1016/j.psyneuen.2010.07.013
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发表时间：
2011-02-01
影响因子：
3.7
通讯作者：
Voshaar, R. C. Oude
中科院分区：
文献类型：
--
作者：
Bus, B. A. A.;Molendijk, M. L.;Voshaar, R. C. Oude
背景资料：脑源性神经营养因子（BDNF）属于神经营养因子家族，影响成年中枢神经系统神经元的存活和可塑性。皮质和血清BDNF水平之间的高度相关性导致了许多关于不同人群中BDNF水平的人体研究，但是缺乏关于影响BDNF的决定因素的知识。目的：深入了解影响人类BDNF水平的因素。方法：在1168名年龄在18岁到65岁之间的人中，没有抗抑郁药和目前的精神疾病，从荷兰抑郁症和焦虑症的研究四类决定因素（抽样，社会人口，生活方式指标和疾病）进行了测量，以及BDNF水平。我们使用单变量分析以及多元线性回归分析，特别是确定哪些可能的决定因素显着影响血清BDNF levels.Results：平均BDNF水平为8.98 ng/ml（SD 3.1 ng/ml），范围从1.56 ng/ml到18.50 ng/ml。我们最终的多变量回归分析显示，非空腹状态的抽血（β = -.067; p = .019），较晚的测量（β = -.065; p = .022），较长的样本储存（β = -.082; p = .004）和酗酒（β = -.063; p = .035）都导致BDNF水平减弱。这与吸烟（β =-0.098; p = 0.001）和生活在城市地区（β = 0.109; p <0.001）形成对比，后者导致BDNF水平增加。此外，我们发现老年受试者的脑源性神经营养因子水平也较高，但这仅适用于女性（β = 0.226; p <0.001）。结论：未来对人类血清脑源性神经营养因子水平的研究应根据抽血时间、储存时间、城市化程度、年龄、性别、吸烟状况以及食物和酒精摄入量进行校正。(C)2010爱思唯尔有限公司保留所有权利。
Background: Brain-derived neurotrophic factor (BDNF) belongs to the neurotrophin family of growth factors and affects the survival and plasticity of neurons in the adult central nervous system. The high correlation between cortical and serum BDNF levels has led to many human studies on BDNF levels in various populations, however knowledge about determinants that influence BDNF is lacking.Aims: To gain insight into the factors that influence BDNF levels in humans.Methods: In 1168 people aged 18 through 65, free of antidepressants and current psychiatric disease, from the Netherlands study of depression and anxiety four categories of determinants (sampling, sociodemographics, lifestyle indicators and diseases) were measured as well as BDNF level. We used univariate analyses as well as multivariate linear regression analyses in particular to determine which of the possible determinants significantly influenced serum BDNF levels.Results: The mean BDNF level was 8.98 ng/ml (SD 3.1 ng/ml) with a range from 1.56 ng/ml through 18.50 ng/ml. Our final multivariate regression analysis revealed that a non-fasting state of blood draw (beta = -.067; p = .019), later measurement (beta = -.065; p = .022), longer sample storage (beta = -.082; p = .004) and being a binge drinker (beta = -.063; p = .035) all resulted in attenuated BDNF levels. This was in contrast to smoking (beta = -.098; p = .001) and living in an urban area (beta = .109; p < .001), which resulted in increased BDNF levels. Moreover we found that older subjects also had higher BDNF levels, but this only applied to women (beta = .226; p < .001).Conclusions: Future studies on serum levels of BDNF in humans should correct for the time of blood withdrawal, storage, urbanicity, age, sex, smoking status and food and alcohol intake. (C) 2010 Elsevier Ltd. All rights reserved.