Impact of the gut microbiota, prebiotics, and probiotics on human health and disease.
Impact of the gut microbiota, prebiotics, and probiotics on human health and disease.
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DOI：
10.4103/2319-4170.138314
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发表时间：
2014-09-01
影响因子：
5.5
通讯作者：
Lai, Hsin-Chih
中科院分区：
文献类型：
--
作者：
Lin, Chuan-Sheng;Chang, Chih-Jung;Lai, Hsin-Chih
最近的研究表明，肠道微生物群调节许多生理功能，从能量调节和认知过程到毒素中和和对病原体的免疫力。因此，肠道微生物群组成的改变已被证明有助于各种慢性疾病的发展。本综述的主要目的是介绍肠道微生物群研究的最新突破，并表明肠道细菌在不同疾病的发展中起着关键作用，包括肥胖，脂肪肝和肺部感染。我们还强调了益生元和益生菌在保持最佳健康和治疗慢性炎症和免疫相关疾病方面的潜在应用。
Recent studies have revealed that the gut microbiota regulates many physiological functions, ranging from energy regulation and cognitive processes to toxin neutralization and immunity against pathogens. Accordingly, alterations in the composition of the gut microbiota have been shown to contribute to the development of various chronic diseases. The main objectives of this review are to present recent breakthroughs in the study of the gut microbiota and show that intestinal bacteria play a critical role in the development of different disease conditions, including obesity, fatty liver disease, and lung infection. We also highlight the potential application of prebiotics and probiotics in maintaining optimal health and treating chronic inflammatory and immunity-related diseases.