The roles of NOD like receptors in inflammation are different between Japanese and Caucasian.
The roles of NOD like receptors in inflammation are different between Japanese and Caucasian.
复制标题
NOD 样受体在炎症中的作用在日本人和白种人之间是不同的。
DOI：
10.2492/inflammregen.31.196
复制
发表时间：
2011
影响因子：
8.1
通讯作者：
Yasuyuki Fujita
中科院分区：
文献类型：
--
作者：
T. Tanabe;Natsu Yamaguchi;Y. Eishi;Yasuyuki Fujita
核苷酸结合和寡聚化结构域(NOD)样受体(NLRs)是天然免疫系统的成员，识别胞浆中的病原体。我们之前已经发现，NLRs的组成部分NOD1和NOD2的多种基因变异与几种肉芽肿性疾病的易感性有关。值得注意的是，NOD2功能丧失和功能获得突变分别显示出对克罗恩病和布劳综合征的易感性。此外，我们还发现，由于NOD1基因的多态导致的细胞内痤疮丙酸杆菌识别障碍与日本人群中结节病的易感性增加有关。在这篇综述中，我们考察了NOD1和NOD2在先天免疫中的作用，重点讨论了它们在日本人和高加索人之间疾病发病机制中的不同作用。
Nucleotide binding and oligomerization domain (NOD)-like receptors (NLRs) are members of the innate immune system that recognize pathogens in the cytosol. We have previously revealed that multiple genetic variants of NOD1 and NOD2, components of NLRs, are associated with susceptibility to several granulomatous diseases. Notably, NOD2 loss-of-function and gain-of-function mutations showed susceptibility to Crohn's disease and Blau syndrome, respectively. Furthermore, we have revealed that impaired recognition of intracellular Propionibacterium acnes resulting from a polymorphism in the NOD1 gene is involved in the increased susceptibility of Sarcoidosis in a Japanese population. In this review, we examine the function of NOD1 and NOD2 in innate immunity, with a focus on their differing roles in disease pathogenesis between Japanese and Caucasian populations.