Functional disability in rheumatoid arthritis patients compared with a community population in Finland
Functional disability in rheumatoid arthritis patients compared with a community population in Finland
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DOI：
10.1002/art.10731
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发表时间：
2003-01-01
影响因子：
--
通讯作者：
Hannonen, P
中科院分区：
文献类型：
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作者：
Sokka, T;Krishnan, E;Hannonen, P
Objective.比较类风湿关节炎（RA）患者的健康评估问卷（HAQ）评分与性别和年龄调整人群的HAQ评分。RA患者（n = 1，095）和对照组（n = 1，530）完成了一份邮寄的问卷调查，包括HAQ、疼痛和总体健康评分、教育水平和合并症，以及身高、体重和生活方式态度，包括吸烟和锻炼习惯。患者和对照组的HAQ评分随着年龄的增长而增加（表明功能下降）。年龄在30-79岁的RA女性患者中有17-45%和男性患者中有7-32%的HAQ评分高于参考值（年龄和性别匹配人群HAQ评分的第95百分位数），而年龄大于或等于80岁的患者的HAQ评分与年龄和性别匹配人群相似。在逻辑回归模型中，残疾的优势比（HAQ评分大于或等于1;在大多数日常生活活动中至少有一些困难）为7.7（95%置信区间5.3-11.1; P < 0.001），当调整年龄、性别、教育、吸烟、运动、体重指数、合并症数量，和疼痛。结论。与同一社区成年人的一般人群相比，RA与>7岁的残疾风险相关。由于类风湿关节炎的残疾的影响似乎是更大的年轻人和中年人比老年患者。
Objective. To compare Health Assessment Questionnaire (HAQ) scores of patients with rheumatoid arthritis (RA) with HAQ scores from a sex- and age-adjusted population.Methods. Patients with RA (n = 1,095) and control subjects (n = 1,530) completed a mailed questionnaire that comprised the HAQ, pain and global health scores, education level, and comorbidities, as well as height, weight, and lifestyle attitudes, including smoking and exercise habits.Results. The HAQ scores increased (indicating declining function) with older age in patients and controls. The HAQ scores were above the reference values (>95th percentile of the HAQ scores of the age- and sex-matched population) in 17-45% of women with RA and in 7-32% of men with RA ages 30-79 years, while the HAQ scores of the patients greater than or equal to80 years were similar to those of the age- and sex-matched population. In a logistic regression model, the odds ratio for disability (HAQ score greater than or equal to1; at least some difficulties in most activities of daily living) was 7.7 (95% confidence interval 5.3-11.1; P < 0.001) among patients with RA compared with community controls, when adjusted for age, sex, education, smoking, exercise, body mass index, number of comorbidities, and pain.Conclusion. RA is associated with a >7-old risk of disability compared with that in a general population of adults in the same community. The impact of disability due to RA appears to be greater in younger and middle-age people than in elderly patients.