Fluoxetine-treated male wrasses exhibit low AVT expression.
Fluoxetine-treated male wrasses exhibit low AVT expression.
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氟西汀治疗的雄性濑鱼表现出低 AVT 表达。
DOI：
10.1016/j.brainres.2004.09.030
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Godwin,John
中科院分区：
文献类型：
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作者：
Semsar,Katharine;Perreault,HeidiAN;Godwin,John
在许多物种中，增加多巴胺能活性可以减少侵略和逆转优势关系。这些作用可能部分是通过与精氨酸催产素/加压素（AVT/AVP）系统的相互作用介导的。我们测试了这一假设在领土的珊瑚礁鱼，蓝头濑鱼（Thalassoma bifasciatum），通过实验增强多巴胺能神经传递，使用选择性5-羟色胺再摄取抑制剂（SSRI）氟西汀。终末期（TP）雄性动物接受2周的每晚腹膜内氟西汀注射（6 μg/g体重），然后测试其对入侵者的攻击性反应，并杀死以检查下丘脑视前区（POA）中的AVT表型，POA是鱼类社会行为的重要区域。我们先前发表的研究表明，氟西汀治疗的男性侵略性较低[H.A.N. Perreault，K. Semsar，J. Godwin，氟西汀治疗减少了珊瑚礁鱼的领土侵略，Physiol和Behav。79（2003）719-724。在此，对这些相同的氟西汀处理雄性动物的进一步研究显示，在POA的所有区域中，AVT mRNA表达相对于生理盐水处理对照组约低2倍（所有p≤0.05），而AVT-ir索马大小无任何变化（所有p>0.4）。这项研究实验支持的假设，SSRIs的行为效应可能是通过与AVT/AVP系统的相互作用介导的。这些结果与啮齿类动物和人类的研究结果一致，并且与SSRI对AVT/AVP系统的影响的间接神经类固醇生成机制一致，而不仅仅是直接的多巴胺能机制。此外，他们认为SSRI对神经内分泌功能的影响可能最好在具有敏感应激反应的动物中建模，例如在非驯养动物中发现的那些。
In many species, increasing serotonergic activity can reduce aggression and reverse dominance relationships. These effects may in part be mediated through interactions with the arginine vasotocin/vasopressin (AVT/AVP) system. We tested this hypothesis in a territorial coral reef fish, the bluehead wrasse (Thalassoma bifasciatum), by experimentally enhancing serotonergic neurotransmission, using the selective serotonin re-uptake inhibitor (SSRI) fluoxetine. Terminal phase (TP) males received 2 weeks of nightly intraperitoneal fluoxetine injections (6 μg/g body weight) and were then tested for their aggressive response to an intruder and killed to examine AVT phenotype in the preoptic area of the hypothalamus (POA), an area important to social behavior in fishes. Our previously published study demonstrated that fluoxetine-treated males are less aggressive [H.A.N. Perreault, K. Semsar, J. Godwin, Fluoxetine treatment decreases territorial aggression in a coral reef fish, Physiol. and Behav. 79 (2003) 719–724.]. Here, further study of these same fluoxetine-treated males shows approximately twofold lower AVT mRNA expression relative to saline-treated controls in all regions of the POA (all p≤0.05) without any changes in AVT-ir soma size (all p>0.4). This study experimentally supports the hypothesis that behavioral effects of SSRIs may be mediated in part through interactions with the AVT/AVP system. These results parallel findings from rodents and humans and are consistent with an indirect neurosteroidogenic rather than a solely direct serotonergic mechanism for SSRI effects on the AVT/AVP system. Furthermore, they suggest that SSRI effects on neuroendocrine function may be best modeled in animals with sensitive stress responses such as those found in nondomesticated animals.