Dopamine signaling regulates predator-driven changes in Caenorhabditis elegans' egg laying behavior.
Dopamine signaling regulates predator-driven changes in Caenorhabditis elegans' egg laying behavior.
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多巴胺信号传导调节了秀丽隐杆线虫卵形卵形行为的捕食者驱动的变化。
DOI：
10.7554/elife.83957
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发表时间：
2023-07-11
期刊：
影响因子：
7.7
通讯作者：
Chalasani SH
中科院分区：
文献类型：
--
作者：
Pribadi A;Rieger MA;Rosales K;Reddy KC;Chalasani SH
猎物通过改变自己的行为来优化自己的适应和生存。具体来说，猎物会避开捕食者占领的领土，以减少对自己和后代造成伤害或伤害的风险。我们探测秀丽隐杆线虫和它的自然同居捕食者Pritionchus uniformis之间的相互作用，揭示了驱动猎物行为变化的途径。而C.线虫喜欢在细菌食物草坪上产卵，草坪内捕食者的存在诱导了C.在远离草坪的地方产卵我们证实，这种产卵的变化是在回应捕食者的叮咬，而不是捕食性分泌物。此外，即使在捕食者被移除后，暴露在捕食者面前的猎物仍然会继续在远离密集草坪的地方产卵，这表明了一种学习形式。接下来，我们发现多巴胺合成的突变体显着减少产卵行为的草坪在无捕食者和捕食者居住的草坪，我们可以拯救转基因互补或补充外源多巴胺。此外，我们发现，多巴胺可能是从多个多巴胺能神经元释放，并需要D1-（DOP-1）和D2样（DOP-2和DOP-3）多巴胺受体的组合，以改变捕食者诱导的产卵行为，而其他组合修改产卵行为的基线水平。总之，我们表明，多巴胺信号可以改变无捕食者和捕食者诱导的觅食策略，这表明了防御行为中的作用，这一途径。
Prey respond to predators by altering their behavior to optimize their own fitness and survival. Specifically, prey are known to avoid predator-occupied territories to reduce their risk of harm or injury to themselves and their progeny. We probe the interactions between Caenorhabditis elegans and its naturally cohabiting predator Pristionchus uniformis to reveal the pathways driving changes in prey behavior. While C. elegans prefers to lay its eggs on a bacteria food lawn, the presence of a predator inside a lawn induces C. elegans to lay more eggs away from that lawn. We confirm that this change in egg laying is in response to bites from predators, rather than to predatory secretions. Moreover, predator-exposed prey continue to lay their eggs away from the dense lawn even after the predator is removed, indicating a form of learning. Next, we find that mutants in dopamine synthesis significantly reduce egg laying behavior off the lawn in both predator-free and predator-inhabited lawns, which we can rescue by transgenic complementation or supplementation with exogenous dopamine. Moreover, we find that dopamine is likely released from multiple dopaminergic neurons and requires combinations of both D1- (DOP-1) and D2-like (DOP-2 and DOP-3) dopamine receptors to alter predator-induced egg laying behavior, whereas other combinations modify baseline levels of egg laying behavior. Together, we show that dopamine signaling can alter both predator-free and predator-induced foraging strategies, suggesting a role for this pathway in defensive behaviors.
影响因子：
3.4
作者：
Click A;Savaliya CH;Kienle S;Herrmann M;Pires-daSilva A
通讯作者：
Pires-daSilva A
偏远的热带雨林中caenorhabditis的物种丰富度，分布和遗传多样性。
影响因子：
3.4
作者：
Félix MA;Jovelin R;Ferrari C;Han S;Cho YR;Andersen EC;Cutter AD;Braendle C
通讯作者：
Braendle C