Long-term Exercise Training in Overweight Adolescents Improves Plasma Peptide YY and Resistin
Long-term Exercise Training in Overweight Adolescents Improves Plasma Peptide YY and Resistin
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DOI：
10.1038/oby.2009.11
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发表时间：
2009-06-01
期刊：
影响因子：
6.9
通讯作者：
Hickner, R. C.
中科院分区：
文献类型：
--
作者：
Jones, Terry E.;Basilio, J. L.;Hickner, R. C.
本研究的目的是调查长期运动训练对超重青少年与食欲和胰岛素抵抗相关的五种激素浓度的影响。此外，我们对这些激素之间的关系以及与人体测量和/或心血管疾病标志物变化的关系感兴趣。参与者的年龄和性别 BMI ≥ 85%，并参加了为期 8 个月的监督有氧训练计划。在训练前后采集人体测量学、心血管健康评估和空腹血样。测量了葡萄糖、胰岛素、总胆固醇 (TC)、高密度脂蛋白 (HDL) 胆固醇、低密度脂蛋白 (LDL) 胆固醇、甘油三酯、瘦素、活性生长素释放肽、总肽 YY (PYY)、脂联素和抵抗素浓度。参与者在增量跑步机测试中增加了疲惫的时间，并降低了身体脂肪百分比和血液甘油三酯浓度。长期运动训练后，总PYY浓度升高，抵抗素浓度降低，这是有利的结果。瘦素浓度与训练前后的体重、体脂百分比、腰围和甘油三酯浓度有关。抵抗素浓度的变化与甘油三酯浓度的变化有关。我们得出的结论是，长期运动训练对超重青少年的 PYY 和抵抗素、与食欲和胰岛素敏感性相关的激素有有益影响。
The objective of this study was to investigate the effect of long-term exercise training on concentrations of five hormones related to appetite and insulin resistance in overweight adolescents. In addition, we were interested in the relationships of these hormones with each other and with anthropometric and/or cardiovascular disease marker changes. Participants were >= the 85th percentile for BMI for age and sex and participated in an 8-month supervised aerobic training program. Anthropometrics, cardiovascular fitness assessment, and fasting blood samples were taken pre- and post-training. Glucose, insulin, total cholesterol (TC), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, leptin, active ghrelin, total peptide YY (PYY), adiponectin, and resistin concentrations were measured. The participants increased their time to exhaustion on an incremental treadmill test and decreased both percent body fat and blood triglyceride concentrations. Total PYY concentration increased and resistin concentration decreased after long-term exercise training, which are favorable outcomes. Leptin concentrations were related to weight, percent body fat, waist circumference, and triglyceride concentrations pre- and post-training. The changes in resistin concentrations were related to the changes in triglyceride concentrations. We conclude that long-term exercise training has beneficial effects for overweight adolescents with respect to PYY and resistin, hormones related to appetite and insulin sensitivity.