Altered anterior-posterior connectivity through the arcuate fasciculus in temporal lobe epilepsy.
Altered anterior-posterior connectivity through the arcuate fasciculus in temporal lobe epilepsy.
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DOI：
10.1002/hbm.23319
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发表时间：
2016-12
影响因子：
4.8
通讯作者：
Stufflebeam SM
中科院分区：
文献类型：
--
作者：
Takaya S;Liu H;Greve DN;Tanaka N;Leveroni C;Cole AJ;Stufflebeam SM
在癫痫患者的认知过程中，皮层之间通过特定的白色通路的相互作用如何变化仍不清楚。在这里，我们使用基于表面的结构连接分析，以检查与布罗卡区/右侧布罗卡同源物在侧颞叶和下顶叶皮质通过弓状束（AF）的结构连接的变化与左颞叶癫痫（TLE）的17例患者与17名健康对照组相比。然后，我们调查了它的功能相关性的变化，任务相关的反应和任务调制的功能连接与布罗卡区/右布罗卡的同系物在一个单一的词的语义分类任务。左侧颞中皮层通过AF通路的结构连接和与布罗卡区的任务调制功能连接减少。此外，任务相关反应减少的左侧颞中皮层，重叠的区域显示出减少的结构连接。相反，通过AF显示结构连接性增加的区域与左下顶叶皮层中显示任务调制功能连接性增加的区域重叠。重叠区域的这些结构和功能变化是相关的。结果表明，通过左额颞叶AF通路的结构连接的变化是左TLE患者在语言相关处理过程中额叶和颞叶皮质之间功能网络改变的基础。左额-顶叶AF通路可能在语言加工过程中连接前后脑区，并补偿受损的左额-颞叶AF通路。
How the interactions between cortices through a specific white matter pathway change during cognitive processing in patients with epilepsy remains unclear. Here, we used surface-based structural connectivity analysis to examine the change in structural connectivity with Broca’s area/the right Broca’s homologue in the lateral temporal and inferior parietal cortices through the arcuate fasciculus (AF) in 17 patients with left temporal lobe epilepsy (TLE) compared with 17 healthy controls. Then, we investigated its functional relevance to the changes in task-related responses and task-modulated functional connectivity with Broca’s area/the right Broca’s homologue during a semantic classification task of a single word. The structural connectivity through the AF pathway and task-modulated functional connectivity with Broca’s area decreased in the left midtemporal cortex. Furthermore, task-related response decreased in the left mid temporal cortex that overlapped with the region showing a decrease in the structural connectivity. In contrast, the region showing an increase in the structural connectivity through the AF overlapped with the regions showing an increase in task-modulated functional connectivity in the left inferior parietal cortex. These structural and functional changes in the overlapping regions were correlated. The results suggest that the change in the structural connectivity through the left frontal–temporal AF pathway underlies the altered functional networks between the frontal and temporal cortices during the language-related processing in patients with left TLE. The left frontal–parietal AF pathway might be employed to connect anterior and posterior brain regions during language processing and compensate for the compromised left frontal–temporal AF pathway.