Increased density of multiple-head dendritic spines on medium-sized spiny neurons of the striatum in rats reared in a complex environment
Increased density of multiple-head dendritic spines on medium-sized spiny neurons of the striatum in rats reared in a complex environment
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DOI：
10.1006/nlme.1996.0049
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发表时间：
1996-09-01
影响因子：
2.7
通讯作者：
Greenough, WT
中科院分区：
文献类型：
--
作者：
Comery, TA;Stamoudis, CX;Greenough, WT
人们通常认为，大脑不同区域对经验的反应所产生的新突触与已经存在的突触是等价的。理论家们最近提出，涉及多个相关接触的突触构型可能有助于可塑性变化。在复杂程度不同的环境中饲养后，测定了大鼠纹状体背外侧体中型多刺神经元上多头树突棘的数量。将断奶后大鼠分组圈养在充满玩具和物体的环境中，或单独圈养在标准实验室笼中30天。树突状部分高尔基-考克斯浸渍I型多刺神经元的复杂环境中居住的大鼠有大约60%以上的多头棘比那些单独关在笼子里的动物。多头棘可能反映了平行的突触接触，这些接触改变了现有连接的相对强度，或者改变了神经元连接模式的新突触前末端的连接。(C)出版社：Academic Press，Inc.
It has generally been assumed that new synapses added to various brain regions in response to experience are equivalent to those already in existence. Theorists have recently posited that synaptic configurations involving multiple associated contacts may facilitate plastic change. The number of multiple-headed dendritic spines on medium-sized spiny neurons in the rat dorsolateral corpus striatum was determined following rearing in environments differing in complexity. Postweaning rats were either housed as a group in a toy- and object-filled environment or housed individually in standard laboratory cages for 30 days. Dendritic segments of Golgi-Cox impregnated Type I spiny neurons of the complex environment housed rats had approximately 60% more multiple-head spines than those of the individually caged animals. Multiple-head spines may reflect parallel synaptic contacts that modify relative strengths of existing connections or connections with a novel presynaptic terminal that alter the neuron's pattern of connections. (C) 1996 Academic Press, Inc.